Evidence map›Paper›PMID 34982531›Full record

ArticleACS chemical biology2022

Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron.

Gosia M Murawska, Caspar Vogel, Max Jan, Xinyan Lu, Matthias Schild, Mikolaj Slabicki, Charles Zou, Saule Zhanybekova, Manisha Manojkumar, Georg Petzold and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Gosia M MurawskaDepartment of Chemistry, University of Basel, 4056 Basel, Switzerland.
Caspar VogelDepartment of Chemistry, University of Basel, 4056 Basel, Switzerland.
Max JanBroad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States.
Xinyan LuDepartment of Chemistry, University of Basel, 4056 Basel, Switzerland.
Matthias SchildDepartment of Chemistry, University of Basel, 4056 Basel, Switzerland.
Mikolaj SlabickiBroad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States.
Charles ZouBroad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States.
Saule ZhanybekovaDepartment of Chemistry, University of Basel, 4056 Basel, Switzerland.
Manisha ManojkumarBroad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States.
Georg PetzoldFriedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Peter KaiserDepartment of Biological Chemistry, University of California, Irvine, California 92697, United States.
Nicolas ThomäFriedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Benjamin EbertBroad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, United States.
Dennis GillinghamDepartment of Chemistry, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0002-3672-8699
University of Basel · CHBroad Institute · USFriedrich Miescher Institute · CHUniversity of California, Irvine · US

Funding

Ubiquitin SignalingR01GM066164 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KAISER, PETER · 2002 to 2022
$7.4M
NIGMS NIH HHS R01 GM066164
6 · The paper itself

Abstract

We successfully repurpose the DNA repair protein methylguanine methyltransferase (MGMT) as an inducible degron for protein fusions. MGMT is a suicide protein that removes alkyl groups from the O

Indexed as

DNA RepairCell LineCRISPR-Cas SystemsDNA DamageDNA Modification MethylasesDNA Repair EnzymesHumansLigandsTumor Suppressor ProteinsDNA Modification MethylasesDNA Repair EnzymesLigandsMGMT protein, humanTumor Suppressor Proteins

Identifiers

PMID34982531
PMCPMC12677196
OpenAlexW4206789617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.