ArticlePlant molecular biology2022
Potent inhibition of TCP transcription factors by miR319 ensures proper root growth in Arabidopsis.
Article in Plant molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- SlTCP16 confers disease resistance in tomato via a dual regulatory mechanism involving transcriptional activation and protein interaction with Sl4CL3.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Transcription factor LchiTCP1 modulates abiotic stress response in arabidopsis.Functional & integrative genomics · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- Genome-wide identification, classification, and expression pattern analysis of the TCP transcription factor family in carrot.Frontiers in plant science · 2026Article
- Comparative analysis of NAC genes and their expression patterns under various treatments in Dendrobium huoshanense.BMC plant biology · 2025Article
- Genome-wide identification and analysis of miR396 family members and their target GRF genes in rubber tree (Hevea brasiliensis).BMC genomics · 2025Article
- Genome-wide association mapping reveals genetic loci underlying phenotypic variation in early root vigour improvement induced by osmopriming in Brassica napus L.BMC plant biology · 2025Article
- MicroRNA319-TCP19-IAA3.2 Module Mediates Lateral Root Growth inPlants (Basel, Switzerland) · 2025Article
- An organ-specific transcriptome atlas of Curcuma wenyujin: MicroRNAs, phasiRNAs, and metabolic pathways.The plant genome · 2025Article
- Overexpression ofInternational journal of molecular sciences · 2025Article
- Analysis of transcriptome and differential expression of different types of calli of Eucalyptus urophylla × Eucalyptus grandis.PloS one · 2025Article
- Article
- MicroRNAs Involved in Nutritional Regulation During Plant-Microbe Symbiotic and Pathogenic Interactions with Rice as a Model.Molecular biotechnology · 2024Review
- Identification and characterization of the RcTCP gene family and its expression in response to abiotic stresses in castor bean.BMC genomics · 2024Article
- Genome-wide identification and characterization of TCP gene family inFrontiers in plant science · 2024Article
- Advances in Research on the Regulation of Floral Development byCurrent issues in molecular biology · 2023Review
- Integrative Transcriptome, miRNAs, Degradome, and Phytohormone Analysis ofInternational journal of molecular sciences · 2023Article
- Recent Insights into Plant miRNA Biogenesis: Multiple Layers of miRNA Level Regulation.Plants (Basel, Switzerland) · 2023Review
- Genomic characterization and expression analysis ofPlant signaling & behavior · 2022Article
- Overexpression ofInternational journal of molecular sciences · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
key messageProper root growth depends on the clearance of TCP transcripts from the root apical meristem by microRNA miR319. The evolutionarily conserved microRNA miR319 regulates genes encoding TCP transcription factors in angiosperms. The miR319-TCP module controls cell proliferation and differentiation in leaves and other aerial organs. The current model sustains that miR319 quantitatively tunes TCP activity during leaf growth and development, ultimately affecting its size. In this work we studied how this module participates in Arabidopsis root development. We found that misregulation of TCP activity through impairment of miR319 binding decreased root meristem size and root length. Cellular and molecular analyses revealed that high TCP activity affects cell number and cyclin expression but not mature cell length, indicating that, in roots, unchecking the expression of miR319-regulated TCPs significantly affects cell proliferation. Conversely, tcp multiple mutants showed no obvious effect on root growth, but strong defects in leaf morphogenesis. Therefore, in contrast to the quantitative regulation of the TCPs by miR319 in leaves, our data suggest that miR319 clears TCP transcripts from root cells. Hence, we provide new insights into the functions of the miR319-TCP regulatory system in Arabidopsis development, highlighting a different modus operandi for its action mechanism in roots and shoots.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.