ArticleeLife2022
Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 14 citations in OpenAlex.
- A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.Cell reports methods · 2026Article
- A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.bioRxiv : the preprint server for biology · 2026Article
- Multi-Frequency Interpolation X-talk Removal Algorithm: Enabling Combinations of Concurrent Optogenetics and Lock-in Amplification Fiber Photometry via Removal of Optogenetic Stimulation Crosstalk.ACS chemical neuroscience · 2025Article
- Theory of interaction between untuned modulatory inputs and tuned sensory inputs.bioRxiv : the preprint server for biology · 2025Article
- Fast neural population dynamics in primate V1 captured by a genetically-encoded voltage indicator.Research square · 2025Article
- Cellular-resolution optogenetics reveals attenuation-by-suppression in visual cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Single-cell optogenetics reveals attenuation-by-suppression in visual cortical neurons.bioRxiv : the preprint server for biology · 2024Article
- Response sub-additivity and variability quenching in visual cortex.Nature reviews. Neuroscience · 2024Review
- Mechanisms underlying reshuffling of visual responses by optogenetic stimulation in mice and monkeys.Neuron · 2023Article
- Compact deep neural network models of visual cortex.bioRxiv : the preprint server for biology · 2023Article
- Thalamocortical loops as temporal demodulators across senses.Communications biology · 2023Review
- Optogenetic stimulation of the primary visual cortex drives activity in the visual association cortex.Current research in neurobiology · 2023Article
- Behavioral optogenetics in nonhuman primates; a psychological perspective.Current research in neurobiology · 2023Review
- How Do We Connect Brain Areas with Cognitive Functions? The Past, the Present and the Future.NeuroSci · 2022Review
- Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1.eLife · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Can direct stimulation of primate V1 substitute for a visual stimulus and mimic its perceptual effect? To address this question, we developed an optical-genetic toolkit to 'read' neural population responses using widefield calcium imaging, while simultaneously using optogenetics to 'write' neural responses into V1 of behaving macaques. We focused on the phenomenon of visual masking, where detection of a dim target is significantly reduced by a co-localized medium-brightness mask (Cornsweet and Pinsker, 1965; Whittle and Swanston, 1974). Using our toolkit, we tested whether V1 optogenetic stimulation can recapitulate the perceptual masking effect of a visual mask. We find that, similar to a visual mask, low-power optostimulation can significantly reduce visual detection sensitivity, that a sublinear interaction between visual- and optogenetic-evoked V1 responses could account for this perceptual effect, and that these neural and behavioral effects are spatially selective. Our toolkit and results open the door for further exploration of perceptual substitutions by direct stimulation of sensory cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.