Evidence map›Paper›PMID 34981861›Full record

ArticleGlia2022

Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice.

Christiaan F M Huffels, Lana M Osborn, Lianne A Hulshof, Lieneke Kooijman, Lukas Henning, Christian Steinhäuser, Elly M Hol

Open access · greenAbstract read
In one paragraph

Article in Glia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Astrocytic KFrontiers in aging neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Christiaan F M HuffelsDepartment of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-9070-3644
Lana M OsbornSwammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-5900-0246
Lianne A HulshofDepartment of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-6227-4336
Lieneke KooijmanSwammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands.
Lukas HenningInstitute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.
Christian SteinhäuserInstitute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-2579-8357
Elly M HolDepartment of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0001-5604-2603
Utrecht University · NLNetherlands Institute for Neuroscience · NLUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer pathology is accompanied by astrogliosis. Reactive astrocytes surrounding amyloid plaques may directly affect neuronal communication, and one of the mechanisms by which astrocytes impact neuronal function is by affecting K

Indexed as

Alzheimer DiseasePlaque, AmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsAstrocytesDentate GyrusDisease Models, AnimalKcnj10 ChannelMiceMice, TransgenicPotassium Channels, Inwardly RectifyingAmyloid beta-PeptidesAmyloid beta-Protein PrecursorKcnj10 ChannelPotassium Channels, Inwardly RectifyingAlzheimer's diseaseamyloid-β plaquesastrocytesdentate gyrusgliainward rectificationpotassium channelsreactive gliosisRRID:AB_10013382RRID:AB_2040120RRID:AB_2651133RRID:AB_477010RRID:AB_570666RRID:AB_662807

Identifiers

PMID34981861
PMCPMC9306581
OpenAlexW4206788426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.