Evidence map›Paper›PMID 34981848›Full record

ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2022

Clinical applications of personalising the neural components of visual image quality metrics for individual eyes.

Gareth D Hastings, Raymond A Applegate, Alexander W Schill, Chuan Hu, Daniel R Coates, Jason D Marsack

Open access · greenAbstract read
In one paragraph

Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Impact of contact lens correction on wavefront aberrations and vision quality in keratoconus.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
    Review
  2. Article
  3. Dioptric differences between clinically determined and metric-optimised refractions for adults with Down syndrome.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023
    Article
  4. Utilising a visual image quality metric to optimise spectacle prescriptions for eyes with keratoconus.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023
    Article
  5. Art Painting Image Classification Based on Neural Network.Computational intelligence and neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gareth D HastingsCollege of Optometry, University of Houston, Houston, Texas, USA.ORCID 0000-0001-8959-5984
Raymond A ApplegateCollege of Optometry, University of Houston, Houston, Texas, USA.
Alexander W SchillCollege of Optometry, University of Houston, Houston, Texas, USA.
Chuan HuCollege of Optometry, University of Houston, Houston, Texas, USA.
Daniel R CoatesCollege of Optometry, University of Houston, Houston, Texas, USA.
Jason D MarsackCollege of Optometry, University of Houston, Houston, Texas, USA.
University of Houston · USCenter for Innovation · US

Funding

Research Programming ModuleP30EY007551 · NEI · UNIVERSITY OF HOUSTON · PI VALLABH E DAS · 1988 to 2026
$16.4M
Optical aberration and visual performance in highly aberrated eyesR01EY019105 · NEI · UNIVERSITY OF HOUSTON · PI APPLEGATE, RAYMOND A, MARSACK, JASON D · 2009 to 2018
$2.9M
ABERRATIONS OF EYES IN NORMAL CLINICAL POPULATIONR01EY008520 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI APPLEGATE, RAYMOND A · 1991 to 2010
$2.8M
NEI NIH HHS P30 EY007551NEI NIH HHS R01 EY008520NEI NIH HHS R01 EY019105
6 · The paper itself

Abstract

purposeEyecare is evolving increasingly personalised corrections and increasingly personalised evaluations of corrections on-eye. This report describes individualising optical and neural components of the VSX (visual Strehl) metric and evaluates personalisation using two clinical applications. (1) Better understanding visual experience: While VSX tracks visual performance in typical eyes, non-individualised metrics underestimated visual performance in highly aberrated eyes - could this be understood by personalising metrics? (2) Metric-optimised objective spherocylindrical refractions in typical and atypical eyes have used neural weighting functions of typical eyes - will personalisation affect the outcome in clinical 0.25D steps?

methodsOrientation-specific neural contrast sensitivity was measured in four typical myopic and astigmatic eyes and six eyes with keratoconus. Wavefront error was measured in all eyes while uncorrected and when the keratoconic eyes wore wavefront-guided scleral lenses. Total experiment duration was 24-28 h per subject. Two versions of VSX were calculated for each application: one weighted ocular optics with measured neural contrast sensitivity data from that eye, another weighted optics with a representative neural function of typical eyes. Wavefront-guided corrections were evaluated using the two metric values. Spherocylindrical corrections that optimised each metric were identified.

resultsMetric values for keratoconic eyes improved by a mean factor of 1.99 (~0.3 log units) when personalised. Applying this factor to a larger sample of eyes from a previous keratoconus study reconciled dissonances between the percentage of eyes reaching normative best-corrected metric levels and the percentages of eyes reaching normative levels of visual acuity and contrast sensitivity. Spherocylindrical corrections that optimised both versions of VSX were clinically equivalent (mean ± SD Euclidean dioptric difference 0.13 ± 0.18 D).

conclusionsPersonalising visual image quality metrics is beneficial when actual metric values are used (evaluating ophthalmic corrections on-eye against norms) and when fine increments in visual quality are imparted (wavefront-guided corrections). However, partially individualised metrics appear adequate when metrics relatively rank spherocylindrical corrections in 0.25 D steps.

Indexed as

BenchmarkingKeratoconusContrast SensitivityHumansRefraction, OcularVision TestsVisual Acuityaberrationscorneal ectasiaindividualised medicinekeratoconusneural processingvisual image quality

Identifiers

PMID34981848
PMCPMC8833140
OpenAlexW4205468761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.