Evidence map›Paper›PMID 34981677›Full record

ArticleJournal of Korean medical science2022

Prevalence and Premature Mortality Statistics of Autism Spectrum Disorder Among Children in Korea: A Nationwide Population-Based Birth Cohort Study.

Seung-Mi Yoo, Kyoung-Nam Kim, Sungchan Kang, Hyun Joo Kim, Jieun Yun, Jin Yong Lee

Open access · goldAbstract read
In one paragraph

Article in Journal of Korean medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. [Early death and causes of death of patients with autism spectrum disorders: A systematic review].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023
    Pooled it
  5. Article
  6. Article
  7. Article
  8. Sex-Based Differences in Prenatal and Perinatal Predictors of Autism Spectrum Disorder Using Machine Learning With National Health Data.Autism research : official journal of the International Society for Autism Research · 2025
    Article
  9. Observational
  10. Article
  11. Mortality risk among Autistic children and young people: A nationwide birth cohort study.Autism : the international journal of research and practice · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Seung-Mi Yoo *Graduate School of Public Health, Korea University, Seoul, Korea.ORCID https://orcid.org/0000-0003-4080-5543
Kyoung-Nam Kim *Department of Preventive Medicine and Public Health, Ajou University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0002-8715-9238
Sungchan KangGraduate School of Public Health, Seoul National University, Seoul, Korea.ORCID https://orcid.org/0000-0002-4876-3205
Hyun Joo KimDepartment of Nursing Science, Shinsung University, Dangjin, Korea.ORCID https://orcid.org/0000-0001-5784-3576
Jieun YunDepartment of Pharmaceutical Engineering, Cheongju University, Cheongju, Korea.ORCID https://orcid.org/0000-0002-4241-4274
Jin Yong LeePublic Healthcare Center, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-7752-2697
Seoul National University · KRAjou University · KRCheongju University · KRKorea University · KRShinsung University · KR

Funding

Smile Together Foundation
6 · The paper itself

Abstract

backgroundThe aim of this study was to estimate the 8-year prevalence and mortality statistics of autism spectrum disorder (ASD) according to birth year (2002-2012).

methodsWe used the National Health Insurance Service database with 4,989,351 children born from 2002 to 2012 including 35,529 children diagnosed with ASD until 8 years of age. The 8-year cumulative prevalence of ASD was calculated annually (2010-2020) with 8 years of follow-up. The 8-year mortality was estimated using Cox models adjusted for sex, household income, area of residence, and year of birth.

resultsOf the 473,494 children born in 2002, 2,467 (5.2 per 1,000 births) were diagnosed with ASD until 2010. The ASD prevalence was 2.6 times higher among boys (1,839; 7.4 per 1,000 boy births) than girls (628; 2.8 per 1,000 girl births). Of the 467,360 children born in 2012, 4,378 (9.4 per 1,000 births) were diagnosed with ASD until 2020. The ASD prevalence was 2.7 times higher among boys (3,246; 13.5 per 1,000 boy births) than girls (1,132; 5.0 per 1,000 girl births). The risk of all-cause mortality was higher among children with ASD than those without (hazard ratio [HR], 2.340; 95% confidence interval [CI], 2.063-2.654), which is substantially higher among girls (HR, 4.223; 95% CI, 3.472-5.135) than boys (HR, 1.774; 95% CI, 1.505-2.090).

conclusionThe present study demonstrated that national-level prevalence and mortality statistics of ASD can be estimated effectively using claims data comprising newborns born each year and followed up for to the age of interest. Because this information is essential to establish evidence-based policies, health authorities need to consider producing epidemiological information of ASD continuously using the same methodology.

Indexed as

Mortality, PrematureAdolescentAutism Spectrum DisorderChildCohort StudiesFemaleHumansMalePrevalenceRepublic of KoreaYoung AdultAutism Spectrum DisorderMortalityNational Health InsurancePrevalence

Identifiers

PMID34981677
PMCPMC8723892
OpenAlexW4200264087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.