Evidence map›Paper›PMID 34981657›Full record

ArticleESC heart failure2022

Six-months immunogenicity of BNT162b2 mRNA vaccine in heart transplanted and ventricle assist device-supported patients.

Osnat Itzhaki Ben Zadok, Aviv A Shaul, Binyamin Ben-Avraham, Vicky Yaari, Haim Ben Zvi, Noa Eliakim-Raz, Dafna Yahav, Galia Abed, Miriam Abuhazira, Yaron D Barac and 5 more

Open access · goldAbstract read
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Hepatitis A vaccination during ventricular assist device support in heart transplant candidates: immunogenicity and safety in a single-center cohort.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026
    Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Osnat Itzhaki Ben ZadokDepartment of Cardiology, Rabin Medical Center, 39 Jabotinsky St., Petah Tikva, 49100, Israel.
Aviv A ShaulDepartment of Cardiology, Rabin Medical Center, 39 Jabotinsky St., Petah Tikva, 49100, Israel.
Binyamin Ben-AvrahamDepartment of Cardiology, Rabin Medical Center, 39 Jabotinsky St., Petah Tikva, 49100, Israel.
Vicky YaariDepartment of Cardiology, Rabin Medical Center, 39 Jabotinsky St., Petah Tikva, 49100, Israel.
Haim Ben ZviSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Noa Eliakim-RazSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Dafna YahavSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Galia AbedDepartment of Cardiology, Rabin Medical Center, 39 Jabotinsky St., Petah Tikva, 49100, Israel.
Miriam AbuhaziraSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Yaron D BaracSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Israel MatsDepartment of Cardiology, Rabin Medical Center, 39 Jabotinsky St., Petah Tikva, 49100, Israel.
Tzippy ShochatResearch Unit, Rabin Medical Center, Petach Tikva, Israel.
Dan AravotSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ran KornowskiDepartment of Cardiology, Rabin Medical Center, 39 Jabotinsky St., Petah Tikva, 49100, Israel.
Tuvia Ben-GalDepartment of Cardiology, Rabin Medical Center, 39 Jabotinsky St., Petah Tikva, 49100, Israel.
Rabin Medical Center · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo assess the 6 months immunogenicity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine in a population of heart transplanted (HTx) recipients and left ventricular assist device (LVAD)-supported patients. METHODS AND

resultsA prospective single-centre cohort study of HTx recipients and LVAD-supported patients who received a two-dose SARSCoV-2 mRNA vaccine (BNT162b2, Pfizer-BioNTech). Whole blood for anti-spike IgG (S-IgG) antibodies were drawn at 6 months after the first vaccine dose. S-IgG data at 6 weeks were available for a subgroup of HTx recipients. S-IgG ≥ 50 AU/mL were interpreted positive. The cohort included 53 HTx recipients and 18 LVAD-supported patients. The median time from HTx or LVAD implantation to the 1

conclusionsAt 6 months post-vaccination, S-IgG immunogenicity in HTx recipients is low, particularly in older HTx recipients and in those treated with anti-metabolites drugs.

Indexed as

COVID-19Heart-Assist DevicesAgedAntibodies, ViralBNT162 VaccineCohort StudiesCOVID-19 VaccinesHumansmRNA VaccinesProspective StudiesSARS-CoV-2Vaccines, SyntheticAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesmRNA VaccinesVaccines, SyntheticCOVID-19Heart transplantationLeft ventricular assist deviceSARS-CoV-2Vaccine

Identifiers

PMID34981657
PMCPMC8934960
OpenAlexW4205873645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.