ArticleJournal of pineal research2022
Predicting melatonin suppression by light in humans: Unifying photoreceptor-based equivalent daylight illuminances, spectral composition, timing and duration of light exposure.
Article in Journal of pineal research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
- Melatonin suppression does not automatically alter sleepiness, vigilance, sensory processing, or sleep.Sleep · 2022Trial
- Evaluation of wearable light dosimeters for circadian lighting: spectral, spatial, photometric, melanopic, and thermal performance.Npj biological timing and sleep · 2026Article
- The Circadian-Light-Hygiene Hypothesis: A Potential Modulator of Fertility and Birthrate Trends.Biology · 2026Review
- Light Exposure as a Modifiable Determinant of Mental Health.Current psychiatry reports · 2026Review
- Can Morning Light Phase Advance Human Melatonin Rhythms in Less Than 24 h?Journal of pineal research · 2026Review
- Home lighting, blue-light filtering, and their effects on melatonin suppression.Scientific reports · 2026Article
- Lack of strong evidence for cone photoreceptors' contribution to human melatonin suppression and alerting response to light.iScience · 2025Article
- Afternoon to early evening bright light exposure reduces later melatonin production in adolescents.Npj biological timing and sleep · 2025Article
- Wearables in Chronomedicine and Interpretation of Circadian Health.Diagnostics (Basel, Switzerland) · 2025Review
- Mechanism study of exercise intervention on circadian disruption in Alzheimer's disease.Frontiers in neuroscience · 2025Review
- Reconsidering the spectral distribution of light: Do people perceive watts or photons?Lighting research & technology (London, England : 2001) · 2024Article
- Towards an evidence-based integrative lighting score: a proposed multi-level approach.Annals of medicine · 2024Review
- Wearable Light Loggers in Field Conditions: Corneal Light Characteristics, User Compliance, and Acceptance.Clocks & sleep · 2024Article
- The Impact of Pupil Constriction on the Relationship Between Melanopic EDI and Melatonin Suppression in Young Adult Males.Journal of biological rhythms · 2024Article
- Effects of calibrated blue-yellow changes in light on the human circadian clock.Nature human behaviour · 2024Article
- Power Analysis for Human Melatonin Suppression Experiments.Clocks & sleep · 2024Article
- Integrative Lighting Aimed at Patients with Psychiatric and Neurological Disorders.Clocks & sleep · 2023Article
- Seasonal Variation in the Responsiveness of the Melanopsin System to Evening Light: Why We Should Report Season When Collecting Data in Human Sleep and Circadian Studies.Clocks & sleep · 2023Article
- Human-Centric Lighting Research and Policy in the Melanopsin Age.Policy insights from the behavioral and brain sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
Abstract
Light-induced melatonin suppression data from 29 peer-reviewed publications was analysed by means of a machine-learning approach to establish which light exposure characteristics (ie photopic illuminance, five α-opic equivalent daylight illuminances [EDIs], duration and timing of the light exposure, and the dichotomous variables pharmacological pupil dilation and narrowband light source) are the main determinants of melatonin suppression. Melatonin suppression in the data set was dominated by four light exposure characteristics: (1) melanopic EDI, (2) light exposure duration, (3) pupil dilation and (4) S-cone-opic EDI. A logistic model was used to evaluate the influence of each of these parameters on the melatonin suppression response. The final logistic model was only based on the first three parameters, since melanopic EDI was the best single (photoreceptor) predictor that was only outperformed by S-cone-opic EDI for (photopic) illuminances below 21 lux. This confirms and extends findings on the importance of the metric melanopic EDI for predicting biological effects of light in integrative (human-centric) lighting applications. The model provides initial and general guidance to lighting practitioners on how to combine spectrum, duration and amount of light exposure when controlling non-visual responses to light, especially melatonin suppression. The model is a starting tool for developing hypotheses on photoreceptors' contributions to light's non-visual responses and helps identifying areas where more data are needed, like on the S-cone contribution at low illuminances.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.