ArticleAnnals of neurology2022
Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Neuropsychological Changes in Isolated REM Sleep Behavior Disorder: A Systematic Review and Meta-analysis of Cross-sectional and Longitudinal Studies.Neuropsychology review · 2024Pooled it
- Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7-Year Prospective Matched Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Pure Autonomic Failure and Central Synucleinopathy Risk.JAMA neurology · 2026Article
- Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder.Nature communications · 2025Article
- REM density in Parkinson's disease: association with motor, cognitive, autonomic function, and dopaminergic medication.NPJ Parkinson's disease · 2025Article
- Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease.Annals of neurology · 2025Article
- Coffee Consumption Is Associated With Later Age-at-Onset of Parkinson's Disease.Annals of clinical and translational neurology · 2025Article
- Exploring glymphatic system alterations in iRBD and Parkinson's disease using automated DTI-ALPS analysis.NPJ Parkinson's disease · 2025Article
- Ictal SPECT Imaging Findings in Parkinson's Disease with Rapid Eye Movement Sleep Behavior Disorder.Movement disorders clinical practice · 2025Article
- Digital gait biomarkers in Parkinson's disease: susceptibility/risk, progression, response to exercise, and prognosis.NPJ Parkinson's disease · 2025Review
- Validation of automated detection of REM sleep without atonia using in-laboratory and in-home recordings.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Factors associated with phenoconversion of idiopathic rapid eye movement sleep behavior disorder: a prospective study.NPJ Parkinson's disease · 2025Article
- Clinical characteristics and phenoconversion in isolated REM sleep behavior disorder: a prospective single-center study in Korea, compared with Montreal cohort.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder.Future science OA · 2024Article
- Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [NPJ Parkinson's disease · 2024Article
- Navigating the Neurobiology of Parkinson's: The Impact and Potential of α-Synuclein.Biomedicines · 2024Review
- Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset.Nature communications · 2024Article
- Presynaptic Dopaminergic Imaging Characterizes Patients with REM Sleep Behavior Disorder Due to Synucleinopathy.Annals of neurology · 2024Article
- Disclosing the Risk Associated with Isolated REM Behavior Disorder: The Sleep Experts' Perspective.Movement disorders clinical practice · 2024Article
- Risk stratification for phenoconversion in patients with isolated REM sleep behavior disorder. A follow-up study from Turkey.Revista de neurologia · 2024Article
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Authors and funding
25 authors at 16 institutions in 10 countries.
Funding
Abstract
objectiveThis study was undertaken to follow up predictive factors for α-synuclein-related neurodegenerative diseases in a multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD).
methodsPatients with iRBD from 12 centers underwent a detailed assessment for potential environmental and lifestyle risk factors via a standardized questionnaire at baseline. Patients were then prospectively followed and received assessments for parkinsonism or dementia during follow-up. The cumulative incidence of parkinsonism or dementia was estimated with competing risk analysis. Cox regression analyses were used to evaluate the predictive value of environmental/lifestyle factors over a follow-up period of 11 years, adjusting for age, sex, and center.
resultsOf 319 patients who were free of parkinsonism or dementia, 281 provided follow-up information. After a mean follow-up of 5.8 years, 130 (46.3%) patients developed neurodegenerative disease. The overall phenoconversion rate was 24.2% after 3 years, 44.8% after 6 years, and 67.5% after 10 years. Patients with older age (adjusted hazard ratio [aHR] = 1.05) and nitrate derivative use (aHR = 2.18) were more likely to phenoconvert, whereas prior pesticide exposure (aHR = 0.21-0.64), rural living (aHR = 0.53), lipid-lowering medication use (aHR = 0.59), and respiratory medication use (aHR = 0.36) were associated with lower phenoconversion risk. Risk factors for those converting to primary dementia and parkinsonism were generally similar, with dementia-first converters having lower coffee intake and beta-blocker intake, and higher occurrence of family history of dementia.
interpretationOur findings elucidate the predictive values of environmental factors and comorbid conditions in identifying RBD patients at higher risk of phenoconversion. ANN NEUROL 2022;91:404-416.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.