Evidence map›Paper›PMID 34981554›Full record

ArticleBiomedical chromatography : BMC2022

Pharmacokinetic and brain distribution study of an anti-glioblastoma agent in mice by HPLC-MS/MS.

Yaxin Li, Raina Dano, Cathy Li, Wenjing Zhang, Justin D Lathia, Bingcheng Wang, Bin Su

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical chromatography : BMC, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yaxin LiDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.
Raina DanoDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.
Cathy LiDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH, USA.
Wenjing ZhangDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.
Justin D LathiaDepartment of Molecular Medicine, Lerner Research Institute, Cleveland Clinic, and Case Comprehensive Cancer Center, Cleveland, OH, USA.
Bingcheng WangRammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Bin SuDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-0711-441X
Cleveland State University · USCase Western Reserve University · USCleveland Clinic Lerner College of Medicine · USMetroHealth · US

Funding

(PQ1) HIV-infected T-cell exosomes in lung cancer progressionR01CA250067 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JIN, GE, WANG, BINGCHENG · 2020 to 2024
$3.7M
Targeting EphA2 in GlioblastomaR01NS096956 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI WANG, BINGCHENG · 2016 to 2021
$2.6M
Targeting Androgen Receptor-HSP27 Signaling in GlioblastomaR15NS116766 · NINDS · CLEVELAND STATE UNIVERSITY · PI SU, BIN · 2021 to 2025
$891k
NCI NIH HHS R01 CA250067NINDS NIH HHS 1R15NS116766-01A1NINDS NIH HHS R01 NS096956NINDS NIH HHS R15 NS116766
6 · The paper itself

Abstract

Previously compound I showed great anti-glioblastoma activity without toxicity in a mouse xenograft study. In this study, a sensitive and rapid high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated to investigate the pharmacokinetics and brain distribution of compound I in mice. The protein precipitation method was applied to extract the compound from mouse plasma and brain homogenates, and it was then separated using a Kinetex C

Indexed as

Blood-Brain BarrierTandem Mass SpectrometryAdministration, OralAnimalsChromatography, High Pressure LiquidHumansMiceReproducibility of Resultsanti-glioblastomablood-brain barrierHPLC-MS/MSpharmacokinetics

Identifiers

PMID34981554
PMCPMC9008720
OpenAlexW4205490139

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.