ArticleBritish journal of clinical pharmacology2022
Is polypharmacy associated with mortality in the very old: Findings from the Newcastle 85+ Study.
Article in British journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interventions to improve the appropriate use of polypharmacy for older people.The Cochrane database of systematic reviews · 2023Pooled it
- Prevalence and global trends of polypharmacy in patients with chronic kidney disease: A systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Polypharmacy Thresholds that Best Predict Emergency Room Visits and Mortality in Older Adults: A Population-Based Study in Québec, Canada.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Assessing Associations of Three Types of Higher-Risk Medication Use and Mortality in Older Adults.Journal of the American Geriatrics Society · 2026Article
- Medication Non-adherence in Older Adults: Underlying Factors, Potential Interventions and Outcomes.Drugs & aging · 2025Review
- Polypharmacy's Association With Mortality: Confounding From Underlying Morbidity.Journal of the American Geriatrics Society · 2025Article
- Prehospital point-of-care medication burden as a predictor of poor related outcomes in unselected acute diseases.Internal and emergency medicine · 2025Article
- Awareness of national dementia guidelines and management of oldest-old and frail people living with dementia: a European survey of geriatricians.European geriatric medicine · 2025Article
- Association between prescription drugs and all-cause mortality risk in the UK population.Aging cell · 2024Article
- Multidisciplinary medication review during older patient hospitalization according to STOPP/START criteria reduces potentially inappropriate prescriptions: MoPIM cohort study.BMC geriatrics · 2024Article
- Association of medication use with falls and mortality among long-term care residents: a longitudinal cohort study.BMC geriatrics · 2023Article
- Article
- Does polypharmacy shape dependency transitions in the very old? Findings from the Newcastle 85+ Study.Age and ageing · 2022Article
- Is polypharmacy associated with mortality in the very old: Findings from the Newcastle 85+ Study.British journal of clinical pharmacology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polypharmacy is common in the very old (≥85 years), where little is known about its association with mortality. We aimed to investigate the association between polypharmacy and all-cause mortality in the very old, over an 11-year time period. Data were drawn from the Newcastle 85+ Study (741), a cohort of people who were born in 1921 and turned 85 in 2006. Survival analysis was performed using Cox proportional hazards models with time-varying covariates, wherein polypharmacy was operationalised continuously. Each additional medication prescribed was associated with a 3% increased risk of mortality (hazard ratio: 1.03, 95% confidence interval: 1.00-1.06). Amongst the very old, the risks and benefits of each additional medication prescribed should be carefully considered.
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