Evidence map›Paper›PMID 34981434›Full record

ArticleInternational journal of hematology2022

Lymphoma during pregnancy in Japan: a multicenter retrospective cohort study.

Chie Onishi, Momoko Nishikori, Kimikazu Yakushijin, Shingo Kurahashi, Hideyuki Nakazawa, Yasushi Takamatsu, Yoshinori Hashimoto, Hiro Tatetsu, Yuichiro Nawa, Masahiro Yoshida and 5 more

Abstract read
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In one paragraph

Article in International journal of hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Journal of fungi (Basel, Switzerland) · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chie OnishiClinical Research Center, Shimane University Hospital, 89-1 Enya Cho, Izumo, Shimane, 693-8501, Japan. mikami@med.shimane-u.ac.jp.ORCID http://orcid.org/0000-0003-4088-3832
Momoko NishikoriDepartment of Hematology/Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kimikazu YakushijinDepartment of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan.
Shingo KurahashiDepartment of Hematology and Oncology, Toyohashi Municipal Hospital, Toyohashi, Japan.
Hideyuki NakazawaDivision of Hematology, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Yasushi TakamatsuDivision of Medical Oncology, Hematology and Infectious Diseases, Department of Internal of Medicine, Fukuoka University, Fukuoka, Japan.
Yoshinori HashimotoDepartment of Hematology, Tottori Prefectural Central Hospital, Tottori, Japan.
Hiro TatetsuDepartment of Hematology, Rheumatology and Infectious Diseases, Kumamoto University Hospital, Kumamoto, Japan.
Yuichiro NawaDivision of Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan.
Masahiro YoshidaDepartment of Hematology, Osaka City General Hospital, Osaka, Japan.
Tsutomu KobayashiDivision of Hematology and Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tatsuo OyakeDivision of Hematology and Oncology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan.
Shingo YanoDivision of Clinical Oncology and Hematology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Aki OrideDepartment of Obstetrics and Gynecology, Faculty of Medicine, Shimane University, Izumo, Japan.
Ritsuro SuzukiDepartment of Hematology, Shimane University Hospital, Izumo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was conducted to characterize lymphoma occurring during pregnancy and to investigate the outcomes of the patients and the fetuses.

methodsClinical data were gathered retrospectively from 29 patients at 13 participating institutions, and data from 28 eligible patients were analyzed.

resultsSix (21%) patients had Hodgkin lymphoma (HL) and 22 (79%) patients had non-Hodgkin lymphoma (NHL). All patients with HL presented with lymphadenopathy, but 15 (68%) of the 22 patients with NHL presented with extranodal sites only. At the median follow-up period of 1325 (range 6-4461) days, the 5-year overall survival rate was 63% for patients with NHL and 100% for patients with HL. Three of the 13 patients who received chemotherapy during pregnancy (23%) developed Pneumocystis jiroveci pneumonia (PCP). There was 1 intrauterine fetal death, 1 spontaneous abortion in the first trimester, and 15 (54%) preterm births.

conclusionThis study showed a higher proportion of NHL than HL during pregnancy in Japan, which was inconsistent with the proportions observed in Western countries. The high incidence of maternal PCP and preterm birth suggested the need for improvements in our management of lymphoma during pregnancy.

Indexed as

AdultFemaleFollow-Up StudiesHodgkin DiseaseHumansIncidenceJapanLymphadenopathyLymphoma, Non-HodgkinPneumonia, PneumocystisPregnancyPregnancy Complications, InfectiousPregnancy Complications, NeoplasticPregnancy OutcomeRetrospective StudiesSurvival RateExtranodal sitesLymphomaPneumocystis jiroveci pneumoniaPregnancy

Identifiers

PMID34981434

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.