Evidence map›Paper›PMID 34981366›Full record

ArticleJournal of general internal medicine2022

New Antipsychotic Prescribing Continued into Skilled Nursing Facilities Following a Heart Failure Hospitalization: a Retrospective Cohort Study.

Melissa R Riester, Parag Goyal, Lan Jiang, Sebhat Erqou, James L Rudolph, John E McGeary, Nicole M Rogus-Pulia, Caroline Madrigal, Lien Quach, Wen-Chih Wu and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of general internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Acute Antipsychotic Use and Presence of Dysphagia Among Older Veterans with Heart Failure.Journal of the American Medical Directors Association · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Melissa R RiesterDepartment of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA. Melissa_riester@brown.edu.ORCID 0000-0003-2196-0134
Parag GoyalDivision of Cardiology and Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Lan JiangCenter of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Sebhat ErqouCenter of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, RI, USA.
James L RudolphDepartment of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA.
John E McGearyCenter of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Nicole M Rogus-PuliaDepartment of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
Caroline MadrigalDepartment of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA.
Lien QuachCenter of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Wen-Chih WuCenter of Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Andrew R ZulloDepartment of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA.
Brown University · USProvidence VA Medical Center · USCornell University · USUniversity of Wisconsin–Madison · US

Funding

U.S. Deprescribing Research NetworkR24AG064025 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BOYD, CYNTHIA MELINDA, STEINMAN, MICHAEL A. · 2019 to 2023
$9.9M
Safe Cardiometabolic Drug Prescribing to Prevent Injury in Nursing Home ResidentsRF1AG061221 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI BERRY, SARAH DYER · 2019 to 2019
$2.8M
Medications and the Risk of Motor Vehicle Crashes in Older AdultsR01AG065722 · NIA · BROWN UNIVERSITY · PI ZULLO, ANDREW REIS · 2020 to 2023
$2.1M
Nursing Home Prevention of Injury in Dementia (NH PRIDE)R01AG062492 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI BERRY, SARAH DYER, COLON-EMERIC, CATHLEEN S · 2019 to 2021
$1.5M
Impact of Novel Rehabilitative Approaches FOR Dysphagia in Patients with Alzheimer's Disease and Related DementiasK76AG068590 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ROGUS-PULIA, NICOLE M · 2020 to 2023
$1.3M
Opioid use in post-acute hip fracture care: prescribing patterns, effectiveness, and safetyR21AG061632 · NIA · BROWN UNIVERSITY · PI BEAUDOIN, FRANCESCA, ZULLO, ANDREW REIS · 2019 to 2020
$462k
NIA NIH HHS K76 AG068590NIA NIH HHS R01 AG062492NIA NIH HHS R01 AG065722NIA NIH HHS R21 AG061632NIA NIH HHS R24 AG064025NIA NIH HHS RF1 AG061221
6 · The paper itself

Abstract

backgroundMultimorbidity and polypharmacy are common among individuals hospitalized for heart failure (HF). Initiating high-risk medications such as antipsychotics may increase the risk of poor clinical outcomes, especially if these medications are continued unnecessarily into skilled nursing facilities (SNFs) after hospital discharge.

objectiveExamine how often older adults hospitalized with HF were initiated on antipsychotics and characteristics associated with antipsychotic continuation into SNFs after hospital discharge.

designRetrospective cohort.

participantsVeterans without prior outpatient antipsychotic use, who were hospitalized with HF between October 1, 2010, and September 30, 2015, and were subsequently discharged to a SNF. MAIN MEASURES: Demographics, clinical conditions, prior healthcare utilization, and antipsychotic use data were ascertained from Veterans Administration records, Minimum Data Set assessments, and Medicare claims. The outcome of interest was continuation of antipsychotics into SNFs after hospital discharge. KEY

resultsAmong 18,008 Veterans, antipsychotics were newly prescribed for 1931 (10.7%) Veterans during the index hospitalization. Among new antipsychotic users, 415 (21.5%) continued antipsychotics in skilled nursing facilities after discharge. Dementia (adjusted OR (aOR) 1.48, 95% CI 1.11-1.98), psychosis (aOR 1.62, 95% CI 1.11-2.38), proportion of inpatient days with antipsychotic use (aOR 1.08, 95% CI 1.07-1.09, per 10% increase), inpatient use of only typical (aOR 0.47, 95% CI 0.30-0.72) or parenteral antipsychotics (aOR 0.39, 95% CI 0.20-0.78), and the day of hospital admission that antipsychotics were started (day 0-4 aOR 0.36, 95% CI 0.23-0.56; day 5-7 aOR 0.54, 95% CI 0.35-0.84 (reference: day > 7 of hospital admission)) were significant predictors of continuing antipsychotics into SNFs after hospital discharge.

conclusionsAntipsychotics are initiated fairly often during HF admissions and are commonly continued into SNFs after discharge. Hospital providers should review antipsychotic indications and doses throughout admission and communicate a clear plan to SNFs if antipsychotics are continued after discharge.

Indexed as

Antipsychotic AgentsHeart FailureAgedCohort StudiesHospitalizationHumansMedicarePatient DischargeRetrospective StudiesSkilled Nursing FacilitiesUnited StatesAntipsychotic Agentsantipsychotic agentsheart failurehospitalizationnursing homesolder adults

Identifiers

PMID34981366
PMCPMC9550891
OpenAlexW4206280940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.