Evidence map›Paper›PMID 34981308›Full record

ArticleJournal of autism and developmental disorders2022

Defining in Detail and Evaluating Reliability of DSM-5 Criteria for Autism Spectrum Disorder (ASD) Among Children.

C E Rice, L A Carpenter, M J Morrier, C Lord, M DiRienzo, A Boan, C Skowyra, A Fusco, J Baio, A Esler and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Diagnostic Agreement of a Structured Telehealth Adult Autism Assessment.Journal of autism and developmental disorders · 2026
    Article
  4. Psychometric Properties of an Arabic Modified Childhood Autism Rating Scale 2 Standard Form.International journal of methods in psychiatric research · 2025
    Article
  5. Article
  6. Article
  7. DSM-5 based algorithms for the Autism Diagnostic Interview-Revised for children ages 4-17 years.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Transparent deep learning to identify autism spectrum disorders (ASD) in EHR using clinical notes.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

C E RiceEmory University, Atlanta, GA, USA. cqr8@cdc.gov.ORCID http://orcid.org/0000-0002-9574-8024
L A CarpenterMedical University of South Carolina, Charleston, SC, USA.
M J MorrierEmory University, Atlanta, GA, USA.
C LordUniversity of California Los Angeles, Los Angeles, CA, USA.
M DiRienzoCenters for Disease Control and Prevention, Atlanta, GA, USA.
A BoanMedical University of South Carolina, Charleston, SC, USA.
C SkowyraWashington University in St. Louis, St. Louis, MO, USA.
A FuscoRutgers New Jersey Medical School, Newark, NJ, USA.
J BaioCenters for Disease Control and Prevention, Atlanta, GA, USA.
A EslerUniversity of Minnesota, Minneapolis, MN, USA.
W ZahorodnyRutgers New Jersey Medical School, Newark, NJ, USA.
N HobsonIndependent Consultant, Keller, TX, USA.
A MarsHunterdon Healthcare System, Flemington, NJ, USA.
A ThurmNational Institute of Mental Health, Bethesda, MD, USA.
S BishopUniversity of California San Francisco, San Francisco, CA, USA.
L D WigginsCenters for Disease Control and Prevention, Atlanta, GA, USA.

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Neurodevelopmental and Behavioral Phenotyping ZICMH002961 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI THURM, AUDREY · 2017 to 2025
$12.6M
Autism Speaks 7793Autism Speaks 8408CDC HHS DD10-1002foundation for the national institutes of health UL1TR001450Intramural CDC HHS CC999999Intramural NIH HHS ZIC MH002961NCATS NIH HHS UL1 TR001450
6 · The paper itself

Abstract

This paper describes a process to define a comprehensive list of exemplars for seven core Diagnostic and Statistical Manual (DSM) diagnostic criteria for autism spectrum disorder (ASD), and report on interrater reliability in applying these exemplars to determine ASD case classification. Clinicians completed an iterative process to map specific exemplars from the CDC Autism and Developmental Disabilities Monitoring (ADDM) Network criteria for ASD surveillance, DSM-5 text, and diagnostic assessments to each of the core DSM-5 ASD criteria. Clinicians applied the diagnostic exemplars to child behavioral descriptions in existing evaluation records to establish initial reliability standards and then for blinded clinician review in one site (phase 1) and for two ADDM Network surveillance years (phase 2). Interrater reliability for each of the DSM-5 diagnostic categories and overall ASD classification was high (defined as very good .60-.79 to excellent ≥ .80 Kappa values) across sex, race/ethnicity, and cognitive levels for both phases. Classification of DSM-5 ASD by mapping specific exemplars from evaluation records by a diverse group of clinician raters is feasible and reliable. This framework provides confidence in the consistency of prevalence classifications of ASD and may be further applied to improve consistency of ASD diagnoses in clinical settings.

Indexed as

Autism Spectrum DisorderDiagnostic and Statistical Manual of Mental DisordersPatient SelectionChildHumansPopulation SurveillancePrevalenceReproducibility of ResultsAutismAutism spectrum disorderClassificationClinician reliabilityDiagnosisDSM-5

Identifiers

PMID34981308
PMCPMC9250939

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.