Evidence map›Paper›PMID 34981165›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2022

[

Elizabeth J de Koster, Lioe-Fee de Geus-Oei, Adrienne H Brouwers, Eveline W C M van Dam, Lioe-Ting Dijkhorst-Oei, Adriana C H van Engen-van Grunsven, Wilbert B van den Hout, Tamira K Klooker, Romana T Netea-Maier, Marieke Snel and 3 more

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02208544 (Efficacy of [18F]-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02208544 nacompletednot on this map

Efficacy of [18F]-2-fluoro-2-deoxy-D-glucose Positron Emission Tomography (FDG-PET) in Evaluation of Cytological Indeterminate Thyroid Nodules Prior to Surgery: a Multicentre Cost-effectiveness Study

TypeinterventionalSponsorRadboud University Medical CenterRan2015 to 2022Enrolled132ConditionsThyroid Nodule, Thyroid NeoplasmsArmsDiagnostic Thyroid Surgery, Ultrasound of the head and neck, FDG-PET/CT
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Dual-tracerFrontiers in endocrinology · 2025
    Pooled it
  2. Guideline
  3. Molecular Diagnostics and [Thyroid : official journal of the American Thyroid Association · 2024
    Trial
  4. [Molecular imaging and biology · 2023
    Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Enhanced staging of differentiated thyroid carcinoma: integrating [European journal of nuclear medicine and molecular imaging · 2025
    Article
  10. Article
  11. Role of [Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Preoperative stratification of cytologically indeterminate thyroid nodules by [European journal of nuclear medicine and molecular imaging · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Elizabeth J de KosterDepartment of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands. Lisanne.deKoster@radboudumc.nl.
Lioe-Fee de Geus-OeiDepartment of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
Adrienne H BrouwersDepartment of Nuclear Medicine and Molecular Imaging Groningen, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Eveline W C M van DamDepartment of Internal Medicine, Division of Endocrinology, Amsterdam University Medical Centers, Location VU Medical Center, Amsterdam, the Netherlands.
Lioe-Ting Dijkhorst-OeiDepartment of Internal Medicine, Meander Medical Centre, Amersfoort, the Netherlands.
Adriana C H van Engen-van GrunsvenDepartment of Pathology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Wilbert B van den HoutDepartment of Medical Decision Making, Leiden University Medical Center, Leiden, the Netherlands.
Tamira K KlookerDepartment of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, the Netherlands.
Romana T Netea-MaierDepartment of Internal Medicine, Division of Endocrinology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Marieke SnelDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Wim J G OyenDepartment of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
Dennis VriensDepartment of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, the Netherlands.
EfFECTS trial study group
Leiden University Medical Center · NLRadboud University Medical Center · NLAcademic Medical Center · NLAmsterdam University Medical Centers · NLMeander Medisch Centrum · NLRadboud University Nijmegen · NLUniversity Medical Center Groningen · NL

Funding

KWF Kankerbestrijding KUN 2014-6514
6 · The paper itself

Abstract

purposeTo assess the impact of an [

methodsIn this double-blinded, randomised controlled multicentre trial, 132 adult euthyroid patients with scheduled diagnostic surgery for a Bethesda III or IV thyroid nodule underwent [

resultsPatient management was unbeneficial in 42% (38/91 [95% confidence interval [CI], 32-53%]) of patients in the [

conclusionAn [ TRIAL REGISTRATION NUMBER: This trial is registered with ClinicalTrials.gov: NCT02208544 (5 August 2014), https://clinicaltrials.gov/ct2/show/NCT02208544 .

Indexed as

Thyroid NeoplasmsThyroid NoduleAdultFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyTomography, X-Ray ComputedFluorodeoxyglucose F18[18F]FDG-PET/CTIndeterminateThyroid carcinomaThyroid cytologyThyroid noduleThyroid surgery

Identifiers

PMID34981165
PMCPMC9016050
OpenAlexW4206268988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.