ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022
The effects of caffeine on bone mineral density and fracture risk.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Tea consumption and bone health in postmenopausal women: a systematic review and meta-analysis.Archives of osteoporosis · 2025Pooled it
- Coffee and tea consumption on the risk of osteoporosis: a meta-analysis.Frontiers in nutrition · 2025Pooled it
- Association of Coffee and Tea Intake with Bone Mineral Density and Hip Fracture: A Meta-Analysis.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Review
- Association of the Dietary Index for Gut Microbiota with site-specific Osteoporosis: Insights from machine learning applied to a national population.Metabolism open · 2026Article
- Bioactive Compounds in Coffee: Metabolism, Bioavailability and Health Effects-A Review.Molecules (Basel, Switzerland) · 2026Review
- Chronic consumption of energy drinks and the risk of developing metabolic syndrome in rats.PeerJ · 2026Article
- Role of Caffeine and Ethanol in Modulating Expression of Receptor Activator of Nuclear Factor κβ (RANK) and Osteoprotegerin (OPG) during Orthodontic Tooth Movement: An In Vivo Study.Acta medica Philippina · 2026Article
- Observational
- Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in osteoporotic mice.Annals of medicine · 2025Article
- Article
- Beyond the Cup: Coffee Extracts as Modulators of Periodontal Inflammation and Bone Remodeling.Current issues in molecular biology · 2025Review
- Caffeine displays dual effect on RANKL-induced osteoclast differentiation and bone resorption activity via adenosine receptors in RAW 264.7 cells.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025Article
- Caffeine intake is inversely associated with osteoporosis risk based on cross-sectional and genetic evidence.Scientific reports · 2025Article
- Article
- Dietary Intake of Minerals and Potential Human Exposure to Toxic Elements via Coffee Consumption.Biological trace element research · 2025Article
- Causal association among smoking, bitter beverage consumption, and risk of osteoporosis: a two-sample mendelian randomization-based study.Hereditas · 2025Article
- Association of caffeine intake and sleep duration with bone mineral density: a cross-sectional study from National Health and Nutrition Examination Survey between 2011 and 2018.BMC musculoskeletal disorders · 2025Article
- The mediating role of caffeine and biological age in the association between dietary index for gut microbiota and osteoporosis.Frontiers in nutrition · 2025Article
- The association between coffee intake and femoral neck bone mineral density based on the NHANES and Mendelian randomisation study.Journal of nutritional science · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine is a regular part of the diet of many adults (coffee, tea, soft drinks, and energy drinks). Multiple molecular effects of caffeine suggest that it may promote bone loss. Given the extensive consumption of caffeine worldwide, any impact of caffeine consumption on bone strength and/or density would have large population health implications. The most well-established pharmacological effect of caffeine is non-specific antagonism of adenosine receptors. Adenosine regulates bone metabolism in a complex manner, with in vitro studies suggesting that direct stimulation of adenosine A
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.