ArticleJournal of the National Cancer Institute2022
S1417CD: A Prospective Multicenter Cooperative Group-Led Study of Financial Hardship in Metastatic Colorectal Cancer Patients.
Article in Journal of the National Cancer Institute, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Assessing Financial Toxicity in Cancer: A Global Systematic Review and Meta-Analysis Using an Asset Framework.Cancer medicine · 2026Pooled it
- Prevalence and determinants of financial toxicity in patients with colorectal cancer: a systematic review and meta-analysis.International journal for equity in health · 2026Pooled it
- Interventions to mitigate cancer-related medical financial hardship: A systematic review and meta-analysis.Cancer · 2024Pooled it
- Subjective and objective financial toxicity among colorectal cancer patients: a systematic review.BMC cancer · 2024Pooled it
- Treatment of Metastatic Colorectal Cancer: ASCO Guideline.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Pooled it
- Financial Navigation for People Newly Diagnosed With Cancer: Primary Outcomes From the Cancer Financial Experience Randomized Trial.JCO oncology practice · 2025Trial
- Colorectal Cancer Legal and Administrative Burden Support (COLLABS): A Pilot Clinical Trial.JCO oncology practice · 2025Trial
- Prevalence and Risk Factors for Financial Toxicity Among Sarcoma Patients During and Following Treatment Across the Lifespan.Cancer reports (Hoboken, N.J.) · 2026Article
- Return to work experience on structural constraints and gendered differences among nasopharyngeal carcinoma survivors: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Addressing financial and health-related social needs among patients with cancer: Study protocol for CAN-ASSIST pilot clinical trial.Contemporary clinical trials communications · 2026Article
- Financial toxicity trajectories and their association with short-term and long-term health outcomes in Chinese patients with cancer: a prospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Associations between psychological distress and financial hardship for patients with cancer receiving care in Alabama.Journal of cancer survivorship : research and practice · 2026Article
- Financial Hardship, End-of-Life Health Care Use, and Costs in Patients With Cancer.JAMA network open · 2026Article
- Implementing Financial Screening for Adolescents and Young Adults Treated in the Outpatient Oncology Setting.JCO oncology practice · 2026Article
- Housing Insecurity and Threats of Utility Shut-Offs Among Cancer Survivors in the United States, BRFSS 2022-2023.Cancer medicine · 2025Article
- Pilot feasibility of a financial and health-related social needs navigation intervention (AYA-NAV) for adolescents and young adults with Cancer: Study protocol for a prospective, single-arm study.Contemporary clinical trials communications · 2025Article
- Patient-Reported Barriers to Healthcare Access Among Patients with Gastrointestinal Cancer: Insights from 45,000 Participants in the All of Us Research Program.Research square · 2025Article
- Observational
- Social Needs in Cancer Survivors: A Scoping Review and Future Directions.Current oncology reports · 2025Article
- Effectiveness of out-of-pocket cost COMmunication and financial navigation (CostCOM) in cancer patients: Study protocol for ECOG-ACRIN EAQ222CD.Contemporary clinical trials · 2025Article
Corrections and comments
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Authors and funding
12 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundFinancial toxicity is a growing problem in oncology, but no prior studies have prospectively measured the financial impact of cancer treatment in a diverse national cohort of newly diagnosed cancer patients. S1417CD was the first cooperative group-led multicenter prospective cohort study to evaluate financial hardship in metastatic colorectal cancer (mCRC) patients.
methodsPatients aged 18 years or older within 120 days of mCRC diagnosis completed quarterly questionnaires for 12 months. We estimated the cumulative incidence of major financial hardship (MFH), defined as 1 or more of increased debt, new loans from family and/or friends, selling or refinancing home, or 20% or more income decline. We evaluated the association between patient characteristics and MFH using multivariate cox regression and the association between MFH and quality of life using linear regression.
resultsA total of 380 patients (median age = 59.9 years) were enrolled; 77.7% were White, 98.0% insured, and 56.5% had annual income of $50 000 or less. Cumulative incidence of MFH at 12 months was 71.3% (95% confidence interval = 65.7% to 76.1%). Age, race, marital status, and income (split at $50 000 per year) were not statistically significantly associated with MFH. However, income less than $100 000 and total assets less than $100 000 were both associated with greater MFH. MFH at 3 months was associated with decreased social functioning and quality of life at 6 months.
conclusionsNearly 3 out of 4 mCRC patients experienced MFH despite access to health insurance. These findings underscore the need for clinic and policy solutions that protect cancer patients from financial harm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.