Evidence map›Paper›PMID 34981076›Full record

ArticlemedRxiv : the preprint server for health sciences2022

Omicron infection of vaccinated individuals enhances neutralizing immunity against the Delta variant.

Khadija Khan, Farina Karim, Sandile Cele, James Emmanuel San, Gila Lustig, Houriiyah Tegally, Yuval Rosenberg, Mallory Bernstein, Yashica Ganga, Zesuliwe Jule and 24 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Khadija KhanAfrica Health Research Institute, Durban, South Africa.
Farina KarimAfrica Health Research Institute, Durban, South Africa.
Sandile CeleAfrica Health Research Institute, Durban, South Africa.
James Emmanuel SanKwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
Gila LustigCentre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Houriiyah TegallyKwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
Yuval RosenbergDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
Mallory BernsteinAfrica Health Research Institute, Durban, South Africa.
Yashica GangaAfrica Health Research Institute, Durban, South Africa.
Zesuliwe JuleAfrica Health Research Institute, Durban, South Africa.
Kajal ReedoyAfrica Health Research Institute, Durban, South Africa.
Nokuthula NgcoboAfrica Health Research Institute, Durban, South Africa.
Matilda MazibukoAfrica Health Research Institute, Durban, South Africa.
Ntombifuthi MthabelaAfrica Health Research Institute, Durban, South Africa.
Zoey MhlaneAfrica Health Research Institute, Durban, South Africa.
Nikiwe MbathaAfrica Health Research Institute, Durban, South Africa.
Yoliswa MiyaAfrica Health Research Institute, Durban, South Africa.
Jennifer GiandhariKwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
Yajna RamphalKwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
Taryn NaidooAfrica Health Research Institute, Durban, South Africa.
Nithendra ManickchundDepartment of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
Nombulelo MagulaDepartment of Internal Medicine, Nelson R. Mandela School of Medicine. University of Kwa-Zulu Natal.
Salim S Abdool KarimCentre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Glenda GraySouth African Medical Research Council, Cape Town, South Africa.
Willem HanekomAfrica Health Research Institute, Durban, South Africa.
Anne von GottbergNational Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
COMMIT-KZN Team
Ron MiloDepartment of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel.
Bernadett I GosnellDepartment of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
Richard J LessellsKwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
Penny L MooreCentre for the AIDS Programme of Research in South Africa, Durban, South Africa.
Tulio de OliveiraKwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.
Mahomed-Yunus S MoosaDepartment of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.
Alex SigalAfrica Health Research Institute, Durban, South Africa.

Funding

Identification of the HIV Reservoir in Lymph Nodes Using Single Cell RNA-SeqR01AI138546 · NIAID · KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV · PI SIGAL, ALEXANDER · 2018 to 2022
$721k
NIAID NIH HHS R01 AI138546Wellcome Trust
6 · The paper itself

Abstract

Omicron variant (B.1.1.529) infections are rapidly expanding worldwide, often in settings where the Delta variant (B.1.617.2) was dominant. We investigated whether neutralizing immunity elicited by Omicron infection would also neutralize the Delta variant and the role of prior vaccination. We enrolled 23 South African participants infected with Omicron a median of 5 days post-symptoms onset (study baseline) with a last follow-up sample taken a median of 23 days post-symptoms onset. Ten participants were breakthrough cases vaccinated with Pfizer BNT162b2 or Johnson and Johnson Ad26.CoV2.S. In vaccinated participants, neutralization of Omicron increased from a geometric mean titer (GMT) FRNT

Identifiers

PMID34981076
PMCPMC8722619

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.