Evidence map›Paper›PMID 34981046›Full record

ArticlebioRxiv : the preprint server for biology2021

Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen.

Manon Nayrac, Mathieu Dubé, Gérémy Sannier, Alexandre Nicolas, Lorie Marchitto, Olivier Tastet, Alexandra Tauzin, Nathalie Brassard, Guillaume Beaudoin-Bussières, Dani Vézina and 19 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 2 institutions in 2 countries.

Manon NayracCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Mathieu DubéCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Gérémy SannierCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Alexandre NicolasCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Lorie MarchittoCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Olivier TastetCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Alexandra TauzinCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Nathalie BrassardCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Guillaume Beaudoin-BussièresCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Dani VézinaCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Shang Yu GongCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Mehdi BenlarbiCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Romain GasserCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Annemarie LaumaeaCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Catherine BourassaCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Gabrielle Gendron-LepageCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Halima MedjahedCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Guillaume GoyetteCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Gloria-Gabrielle Ortega-DelgadoCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Mélanie LaporteCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Julia NiesslCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Laurie GokoolCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Chantal MorrisseauCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Pascale ArlottoCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Jonathan RichardCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Cécile TremblayCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Valérie Martel-LaferrièreCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Andrés FinziCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Daniel E KaufmannCentre de Recherche du CHUM, Montréal, QC, H2X 0A9 Canada.
Centre Hospitalier de l’Université de Montréal · CAInternational AIDS Vaccine Initiative · US

Funding

Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6M
NIAID NIH HHS UM1 AI144462
6 · The paper itself

Abstract

Spacing of the BNT162b2 mRNA doses beyond 3 weeks raised concerns about vaccine efficacy. We longitudinally analyzed B cell, T cell and humoral responses to two BNT162b2 mRNA doses administered 16 weeks apart in 53 SARS-CoV-2 naïve and previously-infected donors. This regimen elicited robust RBD-specific B cell responses whose kinetics differed between cohorts, the second dose leading to increased magnitude in naïve participants only. While boosting did not increase magnitude of CD4

Identifiers

PMID34981046
PMCPMC8722583
OpenAlexW4200035611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.