Evidence map›Paper›PMID 34980926›Full record

ReviewNature neuroscience2022

Large-scale neural recordings call for new insights to link brain and behavior.

Anne E Urai, Brent Doiron, Andrew M Leifer, Anne K Churchland

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed.

  1. Article
  2. Shallow recurrent decoders for neural and behavioural dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Article
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  7. Review
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  20. Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anne E UraiCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0001-5270-6513
Brent DoironUniversity of Chicago, Chicago, IL, USA.
Andrew M LeiferPrinceton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-5362-5093
Anne K ChurchlandCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. AChurchland@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-3205-3794

Funding

Validating Theoretical Models with Neurophysiology and OptogeneticsU19NS107613 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CAI, LONG · 2018 to 2022
$16.7M
The role of parietal cortex in multisensory decision-makingR01EY022979 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANNE KATHRYN CHURCHLAND · 2013 to 2026
$5.7M
Probing Brain-wide Functional Connectivity During BehaviorDP2NS116768 · NINDS · PRINCETON UNIVERSITY · PI LEIFER, ANDREW MICHAEL · 2019 to 2019
$2.4M
Discovering dynamic computations from large-scale neural activity recordingsR01EB026949 · NIBIB · COLD SPRING HARBOR LABORATORY · PI ENGEL, TATIANA · 2018 to 2020
$1.3M
Neuronal population dynamics within and across cortical areasR01EB026953 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOIRON, BRENT D., SMITH, MATTHEW A · 2018 to 2020
$1.0M
NEI NIH HHS R01 EY022979NIBIB NIH HHS R01 EB026949NIBIB NIH HHS R01 EB026953NINDS NIH HHS DP2 NS116768
6 · The paper itself

Abstract

Neuroscientists today can measure activity from more neurons than ever before, and are facing the challenge of connecting these brain-wide neural recordings to computation and behavior. In the present review, we first describe emerging tools and technologies being used to probe large-scale brain activity and new approaches to characterize behavior in the context of such measurements. We next highlight insights obtained from large-scale neural recordings in diverse model systems, and argue that some of these pose a challenge to traditional theoretical frameworks. Finally, we elaborate on existing modeling frameworks to interpret these data, and argue that the interpretation of brain-wide neural recordings calls for new theoretical approaches that may depend on the desired level of understanding. These advances in both neural recordings and theory development will pave the way for critical advances in our understanding of the brain.

Indexed as

BrainNeuronsHead

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.