ArticleNature genetics2022
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
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Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.
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100citing papers in PubMed, 2 pooled it
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Who cites it
100 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review on the contribution of DNA methylation to hearing loss.Clinical epigenetics · 2024Pooled it
- Multi-omics revolution to promote plant breeding efficiency.Frontiers in plant science · 2022Pooled it
- Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells.Allergy · 2025Trial
- Brain DNA methylation, APOE genotype and Alzheimer's disease neuropathology in a large postmortem cohort.Nature aging · 2026Article
- Advancing Marine Mammal Conservation Through Omics Tools and Integration of Indigenous Ecological Knowledge.Molecular ecology · 2026Review
- Genetic Regulation of DNA Methylation and Its Mediating Role in Blood Pressure: A Genome-Wide Twin Study.MedComm · 2026Article
- Article
- Monoallelic Gene Expression: Stochastic or Clonal? From Detection to Mechanisms and Clinical Significance.International journal of molecular sciences · 2026Review
- DNA methylation-mediated suppression of endocytosis confers resistance to duck hepatitis A virus type 3.Microbiology spectrum · 2026Article
- Population epigenetics: deciphering DNA methylation diversity and its implications for health, disease, and evolution.Molecular biology and evolution · 2026Review
- Analysis of whole genome sequencing and plasma metabolomics unveil genetic determinants and clinical implications for human health.Nature communications · 2026Article
- Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026Review
- Estimating in silico causal effects of DNA methylation on gene expression through genetic anchors in airway epithelium in asthma.Science advances · 2026Article
- The genetic basis for DNA methylation variation across tissues and development.Nature communications · 2026Article
- Transcriptome and DNA Methylation Analyses Provide Insight into Environmental Adaptation in Northern and Southern Populations ofAnimals : an open access journal from MDPI · 2026Article
- Integrating Multi-Omics Atlas to Uncover Genetic and Epigenetic Mechanisms and Reveal Cell State Evolution Across Ecotypes in Male Urological Cancers.International journal of molecular sciences · 2026Article
- Understanding Neurodegenerative Diseases From the -Omics Perspective: Lessons Learnt.Annals of neurology · 2026Review
- Genetic regulation of methylation across East Asian and European populations.Nature communications · 2026Article
- Genetics and environment distinctively shape the human immune cell epigenome.Nature genetics · 2026Article
- ATACdb 2.0: a comprehensive chromatin accessibility database of human and mouse.Nucleic acids research · 2026Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors.
Johann S Hawe *Institute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0003-3890-303X
Rory Wilson *Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6135-3764
Katharina T Schmid *Institute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-7082-1099
Li ZhouLee Kong Chian School of Medicine, Singapore, Singapore.
Lakshmi Narayanan LakshmananLee Kong Chian School of Medicine, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2892-1931
Benjamin C LehneDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Brigitte KühnelInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
William R ScottDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-5467-114X
Matthias WielscherDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Yik Weng YewLee Kong Chian School of Medicine, Singapore, Singapore.
Clemens BaumbachInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Dominic P LeeGenome Institute of Singapore, Singapore, Singapore.
Eirini MarouliCentre for Genomic Health, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-6179-1609
Manon BernardDepartments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.
Liliane PfeifferInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Pamela R Matías-GarcíaInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Matias I AutioGenome Institute of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9579-9617
Stephane BourgeoisWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-9245-9510
Christian HerderGerman Center for Diabetes Research (DZD), partner site Düsseldorf, Düsseldorf, Germany.
Ville KarhunenDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-6064-1588
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Holger ProkischInstitute of Human Genetics, Technical University Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-2379-6286
Wolfgang RathmannGerman Center for Diabetes Research (DZD), partner site Düsseldorf, Düsseldorf, Germany.
Michael RodenGerman Center for Diabetes Research (DZD), partner site Düsseldorf, Düsseldorf, Germany.
Sylvain SebertCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID http://orcid.org/0000-0001-6681-6983
Jean ShinDepartments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7353-5178
Konstantin StrauchChair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-8279-3611
Wilson L W TanGenome Institute of Singapore, Singapore, Singapore.
Stefanie M HauckResearch Unit Protein Science, Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich, Germany.ORCID http://orcid.org/0000-0002-1630-6827
Juliane Merl-PhamResearch Unit Protein Science, Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich, Germany.ORCID http://orcid.org/0000-0002-3422-4083
Harald GrallertInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Eudes G V BarbosaInstitute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München, Neuherberg, Germany.
MuTHER Consortium
Thomas IlligHannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6645-0985
Tomas PausCentre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Canada.ORCID http://orcid.org/0000-0003-1495-9338
Zdenka PausovaDepartments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-7784-1380
Panos DeloukasCentre for Genomic Health, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-9251-070X
Roger S Y FooGenome Institute of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-8079-4618
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-2149-0630
Jaspal S KoonerNational Heart and Lung Institute, Imperial College London, London, UK. j.kooner@ic.ac.uk.ORCID http://orcid.org/0000-0003-2086-4837
Marie LohLee Kong Chian School of Medicine, Singapore, Singapore. marie.loh@ntu.edu.sg.ORCID http://orcid.org/0000-0003-3626-8466
Matthias HeinigInstitute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München, Neuherberg, Germany. matthias.heinig@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0002-5612-1720
Christian GiegerInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. christian.gieger@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0001-6986-9554
Melanie WaldenbergerInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. waldenberger@helmholtz-muenchen.de.ORCID http://orcid.org/0000-0003-0583-5093
John C ChambersLee Kong Chian School of Medicine, Singapore, Singapore. john.chambers@ic.ac.uk.ORCID http://orcid.org/0000-0003-0209-4541
Funding
Genetics of cardiovascular risk factors in large founder population birth controlR01HL087679 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HIRSCHHORN, JOEL N · 2007 to 2009
$4.0MGenetic Influences on ADHD in a Finnish Birth CohortR01MH063706 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALLEY, SUSAN L · 2001 to 2005
$3.3MWhole Genome Assoc. Analysis Strategies for Multi. PhenotypesRL1MH083268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREIMER, NELSON B. · 2007 to 2011
$2.1MBiotechnology and Biological Sciences Research Council BB/J004480/1Biotechnology and Biological Sciences Research Council BB/S020845/1British Heart Foundation RG/14/5/30893British Heart Foundation SP/04/002Medical Research Council G0500539Medical Research Council G0600705Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G1002319Medical Research Council MC_UP_1605/7Medical Research Council MR/L007150/1NHLBI NIH HHS R01 HL087679NIMH NIH HHS R01 MH063706NIMH NIH HHS RL1 MH083268Wellcome Trust 081917Wellcome Trust 081917/Z/07/ZWellcome Trust 084723Wellcome Trust 084723/Z/08/ZWellcome Trust 212945/Z/18/Z
Abstract
We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP-CpG associations (methylation quantitative trait loci (meQTL), P < 10
Indexed as
Genetic VariationArthritis, RheumatoidAsiaBlood PressureBody Mass IndexCD8-Positive T-LymphocytesCpG IslandsDNA MethylationDNA ReplicationEuropeGenome-Wide Association StudyHumansLeukocytesPolymorphism, Single NucleotideQuantitative Trait Loci
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