ReviewNature reviews. Nephrology2022
Patient-centred approaches for the management of unpleasant symptoms in kidney disease.
Review in Nature reviews. Nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06257134 (Impact on Quality of Life of Symptoms Routine E-monitoring Among Dialysis Patients, With Results Notification to Teams. A Cluster Randomised Controlled Trial Nested in a National Registry F-SWIFT), which is not on this map. Cited by 124 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact on Quality of Life of Symptoms Routine E-monitoring Among Dialysis Patients, With Results Notification to Teams. A Cluster Randomised Controlled Trial Nested in a National Registry F-SWIFT (French Symptom Monitoring WIth Feedback Trial)
Who cites it
124 citing papers in PubMed, 3 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Do health coaching interventions have effects in patients with chronic kidney disease? A systematic review and meta-analysis of randomized controlled trials.International urology and nephrology · 2026Pooled it
- Implementing electronic Patient-Reported Outcome Measures in Chronic Kidney Disease: a qualitative systematic review of barriers, enablers, and mechanisms.Health and quality of life outcomes · 2026Pooled it
- Effectiveness of telehealth interventions for palliative care in patients with kidney failure: a systematic review.BMC nephrology · 2025Pooled it
- Improving sleep quality of patients undergoing hemodialysis in Iran through receiving spiritual care program: a randomized controlled trial.Scientific reports · 2025Trial
- Difelikefalin improves itch-related sleep disruption in patients undergoing haemodialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Trial
- Muscle weakness, pain, and fatigue impair daily function in chronic kidney disease: a cross-sectional analysis from the I-RACE study.Renal failure · 2026Article
- Article
- Patient-reported measures in children and adolescents with chronic kidney disease and their validation: A scoping review.Pediatric nephrology (Berlin, Germany) · 2026Article
- The Feasibility of Home-Based Moxibustion for Fatigue in Peritoneal Dialysis: A Randomized Controlled Pilot Trial.Healthcare (Basel, Switzerland) · 2026Article
- Addressing evidence gaps in haemodialysis care: a critical review of clinical trials, technological innovations, and implementation priorities.BMC nephrology · 2026Article
- Beyond Kidney Function: A Neuro-Renal Perspective on Personalized Care in Pediatric Chronic Kidney Disease.Medical sciences (Basel, Switzerland) · 2026Review
- [Symptom burden in chronic kidney disease-nephrological assessment compared to patients' perspectives (SOMA.CK study)].Innere Medizin (Heidelberg, Germany) · 2026Article
- Article
- The Association Between Lifestyle Factors and Sleep Quality in Haemodialysis Patients.Nursing open · 2026Article
- Applications of Machine Learning for Early Diagnosis and Prognosis of Chronic Kidney Disease: Current Evidence.Diagnostics (Basel, Switzerland) · 2026Review
- Associations of Inosine with Gut Microbiota, Metabolic Indicators, and Fluid Homeostasis in Kidney-Related Diarrhea.International journal of molecular sciences · 2026Article
- Deciding between conservative kidney management and dialysis in older people with kidney failure: a narrative review.Clinical kidney journal · 2026Review
- Blood Flow Restriction Training in Hemodialysis Patients: Clinical Benefits, Challenges, and Future Perspectives.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Review
- Developing consensus-based symptom-management guidance for advanced kidney disease: findings from a national Delphi study.BMC nephrology · 2026Article
- Sociodemographic, health, and oral factors associated with health-related quality of life in children and adolescents with chronic kidney disease: a cross-sectional study.BMC public health · 2026Observational
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 11 institutions in 8 countries.
Funding
Abstract
Patients with chronic kidney disease (CKD) frequently experience unpleasant symptoms. These can be gastrointestinal (constipation, nausea, vomiting and diarrhoea), psychological (anxiety and sadness), neurological (lightheadedness, headache and numbness), cardiopulmonary (shortness of breath and oedema), dermatological (pruritus and dry skin), painful (muscle cramps, chest pain and abdominal pain) or involve sexual dysfunction, sleep disorders and fatigue. These symptoms often occur in clusters, with one of them as the lead symptom and others as secondary symptoms. Uraemic toxins (also called uremic toxins) are often considered to be the main cause of CKD-associated symptom burden, but treatment of uraemia by dialysis often fails to resolve them and can engender additional symptoms. Indeed, symptoms can be exacerbated by comorbid conditions, pharmacotherapies, lifestyle and dietary regimens, kidney replacement therapy and ageing. Patients with kidney disease, including those who depend on dialysis or transplantation, should feel actively supported in their symptom management through the identification and targeting of unpleasant symptoms via a tailored palliative care approach. Such an approach may help minimize the burden and consequences of kidney disease, and lead to improved patient outcomes including health-related quality of life and better life participation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.