ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Sex-specific alterations of cortical morphometry in treatment-naïve patients with major depressive disorder.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.Molecular psychiatry · 2025Pooled it
- Influence of sex and systemic lupus erythematosus disease status on cerebral cortex structure.Lupus science & medicine · 2026Trial
- Generalizable and explainable deep learning for brain MRI: a multi-cohort evaluation of 3D architectures for age and sex prediction.Brain informatics · 2026Article
- Brain network centrality following stress in adults with major depressive disorder and childhood trauma.Neurobiology of stress · 2026Article
- Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group.Molecular psychiatry · 2025Article
- Gray matter structural alterations in first-episode drug-naïve adolescents with major depressive disorder: a comprehensive morphological analysis study.Psychological medicine · 2025Article
- Common and sex-specific differences in hypothalamic subunit volumes and their links with depressive symptoms in treatment-naïve patients with major depressive disorder.Brain structure & function · 2025Article
- Sex Differences in Cortical Structural Alterations in Major Depressive Disorder With Suicidal Ideation.Depression and anxiety · 2025Article
- Sex differences in pediatric major depressive episodes: a cross-sectional study on psychiatric symptoms in early-onset mood disorders.Frontiers in psychiatry · 2025Article
- Sex Differences in Depression: Insights from Multimodal Gray Matter Morphology and Peripheral Inflammatory Factors.International journal of molecular sciences · 2024Article
- Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Sex-specific resting state brain network dynamics in patients with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Sex Determines Anterior Cingulate Cortex Cortical Thickness in the Course of Depression.Biological psychiatry global open science · 2024Article
- Focus on the sex-specific neural markers in the discrimination of various degrees of depression.Psychoradiology · 2024Article
- Sex differences of brain cortical structure in major depressive disorder.Psychoradiology · 2023Article
- Sex Differences of the Functional Brain Activity in Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Study.Brain sciences · 2022Article
- A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder.Brain sciences · 2022Article
- Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study.Frontiers in psychiatry · 2022Article
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13 authors.
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Abstract
Major depressive disorder (MDD) shows sex differences in terms of incidence and symptoms, but the neurobiological basis underlying these sex differences remains to be clarified. High resolution T1-weighted Magnetic Resonance Imaging (MRI) scans were obtained from 123 non-comorbid treatment-naïve individuals with MDD and 81 age-, sex-, and handedness-matched healthy controls (HCs). MRI data were preprocessed with FreeSurfer software and four cortical measures were extracted: cortical thickness (CT), surface area (SA), cortical volume (CV), and local gyrification index (LGI). We tested for both sex-specific and sex-nonspecific patterns of cortical anatomic alterations. Regardless of sex, individuals with MDD showed significantly higher LGI in posterior cortex relative to HCs. Significant sex-by-group interactions were observed, and subsequent post-hoc analyses revealed that female individuals with MDD showed significantly lower SA in left ventrolateral prefrontal cortex (vlPFC), lower CV in right rostromedial prefrontal cortex (rmPFC), and higher LGI in left visual cortex compared with sex-matched HCs, whereas the opposite patterns of significant effects were seen in male individuals with MDD relative to their sex-matched HCs. Thus, sex-nonspecific and specific morphometric differences from HCs were found in posterior cortex, while in PFC alterations were highly sex-specific early in the illness course. This may involve sex-specific alterations in brain development or processes related to illness onset. These findings highlight the presence and regional distribution of generalized as well as sex-specific alterations of brain neurobiology in MDD.
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