Evidence map›Paper›PMID 34980629›Full record

ArticleBMJ open2022

Incidence and clearance of oral and cervicogenital HPV infection: longitudinal analysis of the MHOC cohort study.

Andrew F Brouwer, Lora P Campredon, Heather M Walline, Brittany M Marinelli, Christine M Goudsmit, Trey B Thomas, Rachel L Delinger, Yan Kwan Lau, Emily C Andrus, Thankam Nair and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Andrew F BrouwerDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA brouweaf@umich.edu.ORCID 0000-0002-3779-5287
Lora P CampredonDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Heather M WallineDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Brittany M MarinelliDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Christine M GoudsmitDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Trey B ThomasDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Rachel L DelingerDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Yan Kwan LauDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Emily C AndrusDepartment of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
Thankam NairDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Thomas E CareyDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan, USA.
Marisa C Eisenberg *Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4221-830X
Rafael Meza *Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Mechanistic Modeling of Oropharyngeal Cancer Treatment and Recurrence (Supplement)U01CA182915 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EISENBERG, MARISA C, MEZA, RAFAEL · 2014 to 2019
$3.3M
NCATS NIH HHS UL1 TR002240NCI NIH HHS U01 CA182915
6 · The paper itself

Abstract

objectivesThe Michigan HPV and Oropharyngeal Cancer study aimed to evaluate patterns of oral and cervicogenital human papillomavirus (HPV) infection prevalence, incidence, and clearance as well as their relationship to sexual behaviours.

designCohort

settingGeneral public in and around Ann Arbor, Michigan.

participants394 college-age and older-adult participants of both sexes provided oral samples, and 325 completed at least 2 visits. 130 who provided a cervicogenital samples, and 127 completed at least 2 visits. OUTCOMES: Incidence and clearance rates as well as HRs for oral and cervicogenital HPV.

resultsOral HPV infections were transient, with only 16% of genotypes persisting to the next visit. The mean time to clearance of a genotype was 46 days (95% CI 37 to 58). In contrast, cervicogenital infections were more persistent, with 56% of genotypes persisting to the next visit. The mean time to clearance of a genotype was 87 days (95% CI 74 to 102). HPV vaccination was associated with reduced incidence of cervicogenital HPV infection (HR 0.63; 95% CI 0.47 to 0.83) but not oral HPV infection. Incidence of oral HPV infection was associated with 2+ recent deep kissing partners (HR 2.00; 95% CI 1.13 to 3.56). Incidence of both oral (HR: 1.70; 95% CI 1.08 to 2.68) and cervicogenital (HR 2.46; 95% CI 1.69 to 3.59) was associated with 2+ recent sexual partners.

conclusionsDetection of oral HPV was highly transient, but incidence was associated with recent deep kissing and sexual partners. Detection of cervicogenital HPV was more persistent, and incidence was positively associated with recent sexual partners and negatively associated with HPV vaccination.

Indexed as

Oropharyngeal NeoplasmsPapillomavirus InfectionsAdultCohort StudiesFemaleHumansIncidenceMalePapillomaviridaePrevalenceRisk FactorsSexual Behaviorepidemiologygynaecologyotolaryngologypublic healthsexual medicine

Identifiers

PMID34980629
PMCPMC8724815
OpenAlexW4206714353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.