Evidence map›Paper›PMID 34980502›Full record

ArticleEuropean journal of cancer (Oxford, England : 1990)2022

Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.

Matt Lechner, Yoko Takahashi, Mario Turri-Zanoni, Jacklyn Liu, Nicholas Counsell, Mario Hermsen, Raman Preet Kaur, Tianna Zhao, Murugappan Ramanathan, Volker H Schartinger and 91 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of cancer (Oxford, England : 1990), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Molecular Profiling of Olfactory Neuroblastoma Using the AACR Project GENIE Database.Journal of neurological surgery. Part B, Skull base · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Role of somatostatin receptor 2 (SSTR2) in pituitary adenomas.Clinical and translational medicine · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Modified reverse septal flap: A surgical hint.World journal of otorhinolaryngology - head and neck surgery · 2025
    Article
  17. Article
  18. Article
  19. DOTATATE PET Imaging in Olfactory Neuroblastoma and Association with SSTR Expression.Journal of neurological surgery. Part B, Skull base · 2024
    Article
  20. [Clinical analysis of endonasal endoscopic surgery in esthesioneuroblastoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

101 authors at 20 institutions in 8 countries.

Matt LechnerUCL Cancer Institute, University College London, London, UK; Academic Head and Neck Centre, UCL Division of Surgery and Interventional Science, University College London, London, UK; ENT Department, Barts Health NHS Trust, London, United Kingdom; Rhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA. Electronic address: m.lechner@ucl.ac.uk.
Yoko TakahashiDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA.
Mario Turri-ZanoniUnit of Otorhinolaryngology and Head & Neck Surgery, Department of Biotechnology and Life Sciences, ASST Sette Laghi, University of Insubria, Varese, Italy.
Jacklyn LiuUCL Cancer Institute, University College London, London, UK.
Nicholas CounsellCancer Research UK & UCL Cancer Trials Centre, University College London, London, UK.
Mario HermsenDepartment of Head and Neck Oncology, Instituto de Investigacio´n Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncologı´a Del Principado de Asturias (IUOPA), Centro de Investigacio´n Biome´dica en Red (CIBER-ONC), Oviedo, Spain.
Raman Preet KaurDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA.
Tianna ZhaoDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA.
Murugappan RamanathanDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA.
Volker H SchartingerDepartment of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria.
Oscar EmanuelUCL Cancer Institute, University College London, London, UK.
Sam HelmanDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA.
Jordan VargheseDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA.
Jozsef DudasDepartment of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria.
Herbert RiechelmannDepartment of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria.
Susanne SprungInstitute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria.
Johannes HaybaeckInstitute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria; Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University Graz, Graz, Austria.
David HowardHead and Neck Cancer Unit, Imperial College Healthcare NHS Trust, London, UK.
Nils Wolfgang EngelDepartment of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sarah StewartHead and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Laura BrooksHead and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Jessica C PicklesDepartment of Developmental Biology and Cancer & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Thomas S JacquesDepartment of Developmental Biology and Cancer & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Tim R FentonSchool of Biosciences, University of Kent, Canterbury, UK; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Luke WilliamsUCL Division of Surgery and Interventional Science, University College London, London, UK.
Francis M VazRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Paul O'FlynnRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Paul StimpsonRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Simon WangInstitute of Nuclear Medicine, University College London, London, UK.
S Alam HannanRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Samit UnadkatRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Jonathan HughesHead and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Raghav DwivediHead and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Cillian T FordeRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Premjit RandhawaRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Simon GaneRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Jonathan JosephRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Peter J AndrewsRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Gary RoyleUCL Cancer Institute, University College London, London, UK.
Alessandro FranchiDepartment of Translational Research, University of Pisa, Pisa, Italy.
Roberta MaraglianoDepartment of Medicine and Surgery, Unit of Pathology, University of Insubria, Varese, Italy.
Simonetta BattocchioPathology Unit, Department of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Helen Bewicke-CopleyUCL Cancer Institute, University College London, London, UK.
Christodoulos PipinikasUCL Cancer Institute, University College London, London, UK.
Amy WebsterUCL Cancer Institute, University College London, London, UK.
Chrissie ThirlwellUCL Cancer Institute, University College London, London, UK; College of Medicine and Health and Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UK.
Debbie HoStem Cell Institute, University of Cambridge, Cambridge, UK.
Andrew TeschendorffCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, China.
Tianyu ZhuCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, China.
Christopher D SteeleDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA.
Nischalan PillayUCL Cancer Institute, University College London, London, UK.
Bart VanhaesebroeckUCL Cancer Institute, University College London, London, UK.
Ahmed MohyeldinDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, USA.
Juan Fernandez-MirandaDepartment of Neurosurgery, Stanford University School of Medicine, Palo Alto, USA.
Ki Wan ParkRhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA.
Quynh-Thu LeDepartment of Radiation Oncology, Stanford University School of Medicine, Palo Alto, USA.
Robert B WestDepartment of Radiation Oncology, Stanford University School of Medicine, Palo Alto, USA.
Rami SaadeDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA.
R Peter ManesDepartment of Neurosurgery, Yale School of Medicine, New Haven, USA.
Sacit Bulent OmayDepartment of Neurosurgery, Yale School of Medicine, New Haven, USA.
Eugenia M ViningDepartment of Neurosurgery, Yale School of Medicine, New Haven, USA.
Benjamin L JudsonDepartment of Neurosurgery, Yale School of Medicine, New Haven, USA.
Wendell G YarbroughDepartment of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, Chapel Hill, NC, USA.
Maddalena SansoviniTherapeutic Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Nicolini SilviaTherapeutic Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Ilaria GrassiTherapeutic Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Alberto BongiovanniOsteoncology and Rare Tumors Center (CDO-TR), IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
David CapperDepartment of Neuropathology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ulrich SchüllerDepartment of Pediatric Hematology and Oncology, Institute of Neuropathology, And Research Institute Children's Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Selvam ThavarajCentre for Clinical, Oral & Translational Science, King's College London, Department of Head and Neck Pathology, Guy's Hospital, London, UK.
Ann SandisonDepartment of Head and Neck Pathology, Guy's Hospital, London, UK.
Pavol SurdaGuy's Hospital, King's College, London, UK.
Claire HopkinsGuy's Hospital, King's College, London, UK.
Marco FerrariSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padova, Italy.
Davide MattavelliUnit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialities, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Vittorio RampinelliUnit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialities, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Fabio FacchettiPathology Unit, Department of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy.
Piero NicolaiSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padova, Italy.
Paolo BossiMedical Oncology, Department of Medical and Surgical Specialities, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Oswaldo A HenriquezDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA.
Kelly MaglioccaDepartment of Pathology, Emory University School of Medicine, Atlanta, USA.
C Arturo SolaresDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA.
Sarah K WiseDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA.
Jose L LlorenteDept Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Zara M PatelRhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA.
Jayakar V NayakRhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA.
Peter H HwangRhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA.
Peter D LacyDepartment of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland.
Robbie WoodsDepartment of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland.
James P O'NeillDepartment of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland; The Royal College of Surgeons in Ireland, Dublin, Ireland.
Amrita JayDepartment of Histopathology, University College London Hospitals NHS Trust, London, UK.
Dawn CarnellHead and Neck Centre, University College London Hospitals NHS Trust, London, UK.
Martin D ForsterUCL Cancer Institute, University College London, London, UK; Academic Head and Neck Centre, UCL Division of Surgery and Interventional Science, University College London, London, UK; Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Masaru IshiiDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA.
Nyall R LondonDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA; Sinonasal and Skull Base Tumor Program, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA.
Diana M BellDepartment of Pathology, The University of Texas MD Anderson Cancer Center Houston, USA; Division of Anatomic Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, United States.
Gary L GalliaDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA.
Paolo CastelnuovoUnit of Otorhinolaryngology and Head & Neck Surgery, Department of Biotechnology and Life Sciences, ASST Sette Laghi, University of Insubria, Varese, Italy.
Stefano SeveriTherapeutic Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Valerie J LundRoyal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK. Electronic address: v.lund@ucl.ac.uk.
Ehab Y HannaDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address: EYHanna@mdanderson.org.
Royal London Hospital · GBCRUK Lung Cancer Centre of Excellence · GBStanford University · USEmory University · USJohns Hopkins University · USUniversity College London Hospitals NHS Foundation Trust · GBInnsbruck Medical University · ATIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITUniversity of Brescia · ITGuy's Hospital · GBThe University of Texas MD Anderson Cancer Center · USYale University · USUniversität Hamburg · DEUniversity of Insubria · ITBeaumont Hospital · IEGreat Ormond Street Hospital · GBShanghai Institute of Nutrition and Health · CNUniversity College London · GBUniversity of Padua · ITBarts Health NHS Trust · GB

Funding

DEVELOPMENT OF CLINICIAN/RESEARCHERS IN ACADEMIC ENTT32DC000022 · NIDCD · WASHINGTON UNIVERSITY · PI PICCIRILLO, JAY F. · 1989 to 2022
$5.6M
Sinonasal and Skull Base Tumor ProgramZIADC000092 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI LONDON, NYALL · 2020 to 2022
$5.0M
Cancer Research UK 15965Cancer Research UK 25722Department of HealthIntramural NIH HHS Z99 CA999999NIDCD NIH HHS T32 DC000022
6 · The paper itself

Abstract

introductionOlfactory neuroblastoma (ONB) is a rare cancer of the sinonasal region. We provide a comprehensive analysis of this malignancy with molecular and clinical trial data on a subset of our cohort to report on the potential efficacy of somatostatin receptor 2 (SSTR2)-targeting imaging and therapy.

methodsWe conducted a retrospective analysis of 404 primary, locally recurrent, and metastatic olfactory neuroblastoma (ONB) patients from 12 institutions in the United States of America, United Kingdom and Europe. Clinicopathological characteristics and treatment approach were evaluated. SSTR2 expression, SSTR2-targeted imaging and the efficacy of peptide receptor radionuclide therapy [PRRT](

resultsDural infiltration at presentation was a significant predictor of overall survival (OS) and disease-free survival (DFS) in primary cases (n = 278). Kadish-Morita staging and Dulguerov T-stage both had limitations regarding their prognostic value. Multivariable survival analysis demonstrated improved outcomes with lower stage and receipt of adjuvant radiotherapy. Prophylactic neck irradiation significantly reduces the rate of nodal recurrence. 82.4% of the cohort were positive for SSTR2; treatment of three metastatic cases with SSTR2-targeted peptide-radionuclide receptor therapy (PRRT) in the LUTHREE trial was well-tolerated and resulted in stable disease (SD).

conclusionsThis study presents pertinent clinical data from the largest dataset, to date, on ONB. We identify key prognostic markers and integrate these into an updated staging system, highlight the importance of adjuvant radiotherapy across all disease stages, the utility of prophylactic neck irradiation and the potential efficacy of targeting SSTR2 to manage disease.

Indexed as

Esthesioneuroblastoma, OlfactoryNeuroblastomaNose NeoplasmsHumansNasal CavityPositron-Emission TomographyRadioisotopesRadionuclide ImagingReceptors, SomatostatinRetrospective Studiescopper dotatate CU-64RadioisotopesReceptors, Somatostatinsomatostatin receptor 2AdjuvantDiagnostic imagingEsthesioneuroblastomaHumanOlfactoryPrognosisRadiotherapyReceptorsSomatostatinSSTR2 protein

Identifiers

PMID34980502
PMCPMC9554673
OpenAlexW4206584231

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.