Evidence map›Paper›PMID 34980485›Full record

ReviewCurrent problems in cancer2022

Emerging immuno-oncology targets in Myelodysplastic Syndromes (MDS).

Michael Mann, Andrew M Brunner

Open access · greenAbstract readReview
In one paragraph

Review in Current problems in cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Development and Preclinical Evaluation of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  2. High Co-Expression ofJournal of oncology · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael MannBoston University School of Medicine, Department of Medicine, Boston, Massachusetts.
Andrew M BrunnerMassachusetts General Hospital Cancer Center, Leukemia Program, Harvard Medical School, Boston, Massachusetts. Electronic address: abrunner@mgh.harvard.edu.
Boston University · USMassachusetts General Hospital · US

Funding

Targeting SYK Kinase in AMLP50CA206963 · NCI · DANA-FARBER CANCER INST · PI STEGMAIER, KIMBERLY · 2017 to 2021
$10.6M
NCI NIH HHS L30 CA209238NCI NIH HHS P50 CA206963
6 · The paper itself

Abstract

Approaches to immunologic therapies in myelodysplastic syndromes (MDS) have generally fallen into 2 categories: therapies that target immune effector cells and enhance or direct an antileukemic effect, and therapies which target immunological markers on MDS progenitors themselves. Examples of the former include immune checkpoint inhibitors, immunomodulatory therapies, and vaccines, among others, while examples of the latter include antibody-drug conjugate therapies and naked antibodies; while bispecific antibodies and modified T-cells (such as CAR-T therapies) bridge both therapeutic modalities. In this review, we will discuss the rationale for the above therapies, clinical results to date, and potential future directions for investigation.

Indexed as

Myelodysplastic SyndromesNeoplasmsHumansImmunotherapyImmunotherapy, AdoptiveMedical OncologyAdoptive immunotherapyImmunomodulationImmunotherapyMyelodysplastic syndromes

Identifiers

PMID34980485
PMCPMC8860886
OpenAlexW4200006846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.