Observational studyCritical care (London, England)2022
Mechanical power in pediatric acute respiratory distress syndrome: a PARDIE study.
Observational study in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Lung ultrasound feature tracking to quantify regional lung strain in mechanically ventilated pigs.Respiratory research · 2026Article
- Ventilation Intensity and Prognosis in Pediatric Oncology: Mechanical Power, Compliance, and Mortality Risk.Pediatric pulmonology · 2026Observational
- Association of compliance-normalized airway and transpulmonary mechanical power with mortality in PARDS.European journal of pediatrics · 2026Observational
- A novel oxygenation distension index (ODI): a driving pressure-based metric compared with the oxygenation index in pediatric PARDS.European journal of pediatrics · 2026Observational
- Positive end-expiratory pressure in pediatric acute respiratory distress syndrome: a narrative review.Translational pediatrics · 2026Review
- Validation of the Formulas for Mechanical Power in Children and Proposal of the Concept of "Effective Mechanical Power".Journal of clinical medicine · 2026Article
- Does a prior COVID-19 infection affect lung dynamics during thoracic anesthesia?BMC anesthesiology · 2026Article
- Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies.Signal transduction and targeted therapy · 2025Review
- Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients.Annals of intensive care · 2025Article
- Mechanical power made simple: validating a simplified calculation of mechanical power in preterm lungs.Pediatric research · 2025Article
- What every paediatrician needs to know about mechanical ventilation.European journal of pediatrics · 2024Review
- Mechanical power and normalized mechanical power in pediatric acute respiratory distress syndrome.Frontiers in pediatrics · 2024Article
- Association between mechanical ventilation parameters and mortality in children with respiratory failure on ECMO: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Review
- The Impact of Mechanical Energy Assessment on Mechanical Ventilation: A Comprehensive Review and Practical Application.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Pathobiology, Severity, and Risk Stratification of Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023Review
- Endotracheal tube, by the venturi effect, reduces the efficacy of increasing inlet pressure in improving pendelluft.PloS one · 2023Article
- Ventilation-Induced Lung Injury (VILI) in Neonates: Evidence-Based Concepts and Lung-Protective Strategies.Journal of clinical medicine · 2022Review
- The Physiological Basis of High-Frequency Oscillatory Ventilation and Current Evidence in Adults and Children: A Narrative Review.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
20 authors at 19 institutions in 9 countries.
Funding
Abstract
backgroundMechanical power is a composite variable for energy transmitted to the respiratory system over time that may better capture risk for ventilator-induced lung injury than individual ventilator management components. We sought to evaluate if mechanical ventilation management with a high mechanical power is associated with fewer ventilator-free days (VFD) in children with pediatric acute respiratory distress syndrome (PARDS).
methodsRetrospective analysis of a prospective observational international cohort study.
resultsThere were 306 children from 55 pediatric intensive care units included. High mechanical power was associated with younger age, higher oxygenation index, a comorbid condition of bronchopulmonary dysplasia, higher tidal volume, higher delta pressure (peak inspiratory pressure-positive end-expiratory pressure), and higher respiratory rate. Higher mechanical power was associated with fewer 28-day VFD after controlling for confounding variables (per 0.1 J·min
conclusionsHigher mechanical power is associated with fewer 28-day VFDs in children with PARDS. This association is strongest in children < 2-years-old in whom there are notable differences in mechanical ventilation management. While further validation is needed, these data highlight that ventilator management is associated with outcome in children with PARDS, and there may be subgroups of children with higher potential benefit from strategies to improve lung-protective ventilation. TAKE HOME MESSAGE: Higher mechanical power is associated with fewer 28-day ventilator-free days in children with pediatric acute respiratory distress syndrome. This association is strongest in children <2-years-old in whom there are notable differences in mechanical ventilation management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.