Evidence map›Paper›PMID 34980175›Full record

ArticleImmunity & ageing : I & A2022

Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study.

Hui Zhang, Meng Hao, Zixin Hu, Yi Li, Xiaoyan Jiang, Jiucun Wang, Li Jin, Zuyun Liu, Xiaofeng Wang, Xuehui Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity & ageing : I & A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Lack of Immune Resilience Negatively Affects Physical Resilience: Results From the InCHIANTI Follow-Up Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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  6. Early Dysregulation of Angiopoietin-1 and -2 as a Predictor of Mortality in Critically Ill Burn Patients.Journal of burn care & research : official publication of the American Burn Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui Zhang *Human Phenome Institute, Fudan University, Shanghai, China.
Meng Hao *Human Phenome Institute, Fudan University, Shanghai, China.
Zixin Hu *Human Phenome Institute, Fudan University, Shanghai, China.
Yi LiHuman Phenome Institute, Fudan University, Shanghai, China.
Xiaoyan JiangKey Laboratory of Arrhythmias, Ministry of Education, Department of Pathology and Pathophysiology, School of Medicine, Tongji University, Shanghai, China.
Jiucun WangHuman Phenome Institute, Fudan University, Shanghai, China.
Li JinHuman Phenome Institute, Fudan University, Shanghai, China.
Zuyun LiuDepartment of Big Data in Health Science, School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaofeng WangHuman Phenome Institute, Fudan University, Shanghai, China. wangxiaofeng@fudan.edu.cn.
Xuehui SunHuman Phenome Institute, Fudan University, Shanghai, China. xhsun@fudan.edu.cn.

Funding

National Natural Science Foundation of China-Youth Science Fund 3210040426Shanghai Municipal Science and Technology Major Project 2017SHZDZX01the National Key R&D Program of China 2018YFC2000400the National Key R&D Program of China 2018YFC2000400-3the National Key R&D Program of China 2018YFC2002000
6 · The paper itself

Abstract

backgroundThe neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are readily available circulatory immunity markers that are associated with components of frailty. However, few studies have investigated the relationship between these immunity markers and frailty, and it remains unknown whether they are predictive of incident frailty in older adults in general. Hence, we aimed to examine the association of these immunity markers with the risk of incident frailty.

resultsOverall, 1822 older adults (mean age was 78.03 ± 4.46 years) were included in the Rugao Longitudinal Aging Study. NLR, PLR and SII were calculated from blood cell counts. The frailty definition was based on the Fried phenotype. At baseline, 200 (10.98%) individuals were defined as frailty, and no significant associations of NLR, PLR and SII with frailty were found. During the 2-year follow-up, 180 (15.67%) individuals were new-onset frailty. After adjustment, an increased logNLR (odds ratio [OR] 2.92, 95% confidence interval [CI] 1.20-7.18), logPLR (OR 2.54, 95% CI: 1.01-6.53) and logSII (OR 2.34, 95% CI: 1.16-4.78) were significantly associated with a higher risk of incident frailty in all individuals. Additionally, the associations of logNLR (OR 4.21, 95% CI 1.54-11.62 logPLR (OR 3.38, 95% CI: 1.17-9.91) and logSII (OR 2.56, 95% CI: 1.15-5.72) with incident frailty were remained after excluding individuals with comorbidities. In further analyzed, individuals with higher levels of NLR and SII had higher risk of incident frailty when we stratified individuals by quartiles of these immunity markers.

conclusionNLR and SII are easily obtained immunity markers that could be used to predict incident frailty in clinical practice.

Indexed as

BiomarkersEpidemiologyFrailtyImmune function

Identifiers

PMID34980175
PMCPMC8722120

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.