Evidence map›Paper›PMID 34980154›Full record

ArticleJournal of translational medicine2022

Diabetes, hypertension, and cardiovascular disease development.

Fu-Shun Yen, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu, Chii-Min Hwu

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Fu-Shun YenDr. Yen's Clinic, No. 15, Shanying Road, Gueishan District, Taoyuan, 33354, Taiwan.
James Cheng-Chung WeiDepartment of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung City, 40201, Taiwan.
Lu-Ting ChiuManagement Office for Health Data, China Medical University Hospital, 3F., No.373-2, Jianxing Road, Taichung, 40459, Taiwan.
Chih-Cheng HsuInstitute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. cch@nhri.edu.tw.
Chii-Min HwuDepartment of Medicine, National Yang-Ming Chiao Tung University School of Medicine, No.155, Sec.2, Linong Street, Taipei, 11221, Taiwan. chhwu@vghtpe.gov.tw.
China Medical University · TWChung Shan Medical University · TWNational Health Research Institutes · TWNational Yang Ming Chiao Tung University · TW

Funding

most clinical trial consortium for stroke MOST 108-2321-B-039-003seng-lien lin foundation, taichung, and taipei veterans general hospital V105C-204taiwan ministry of health and welfare clinical trial center MOHW109-TDU-B-212-114004
6 · The paper itself

Abstract

backgroundWe aimed to compare cardiovascular risks among participants with T2DM with and without subsequent HTN and participants with HTN with and without subsequent T2DM.

methodsFrom January 1, 2000, to December 31, 2018, we identified 16,236 matched pairs of T2DM participants with and without HTN (T2DM cohorts), 53,509 pairs of HTN participants with and without T2DM (HTN cohorts), and 21,158 pairs of comorbid HTN and T2DM participants with T2DM history or HTN history (comorbid cohorts) from Taiwan's National Health Insurance Research Database. Cox proportional-hazard models were used to calculate the risk of cardiovascular disease.

resultsThe mean follow-up time of this study was 6.75 years. Mean incident rates of coronary artery disease for T2DM cohorts, HTN cohorts, and comorbid cohorts were 16.80, 23.18, and 31.53 per 1000 person-years, respectively. The adjusted hazard ratios (HRs) (95% confidence intervals [95% CIs]) for incident coronary artery disease, stroke, and heart failure in T2DM participants with versus without HTN were 2.22 (2.07-2.37), 1.19 (1.16-1.23), and 0.92 (0.82-1.02), respectively; the adjusted HRs for HTN participants with versus without T2DM were 1.69 (1.55-1.84), 1.25 (1.21-1.30), and 0.98 (0.93-1.05), respectively; the adjusted HRs for comorbid T2DM and HTN participants with previous T2DM versus previous HTN were 2.78 (2.37-3.27), 1.20 (1.13-1.28), and 0.95 (0.88-1.03), respectively.

conclusionsThis nationwide cohort study demonstrated that both T2DM with subsequent HTN and HTN with subsequent diabetes were associated with higher cardiovascular disease risks.

Indexed as

Cardiovascular DiseasesDiabetes MellitusDiabetes Mellitus, Type 2HypertensionCohort StudiesComorbidityHumansRisk FactorsCoronary artery diseaseDiabetes mellitusHeart failureHypertensionStroke

Identifiers

PMID34980154
PMCPMC8722333
OpenAlexW4206421612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.