ArticleBMC cancer2022
Fatigue in breast cancer patients on chemotherapy: a cross-sectional study exploring clinical, biological, and genetic factors.
Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Effects of concurrent aerobic and strength training in women diagnosed with non-metastatic breast cancer: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2026Pooled it
- Quality-of-life measures in pharmacogenomic studies: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Pooled it
- The quality of life assessment of breast cancer patients.Breast disease · 2024Pooled it
- Acupuncture vs. sham acupuncture for cancer-related fatigue in patients with breast cancer: a double-center, randomized, single-blind pilot study.BMC complementary medicine and therapies · 2026Trial
- Multidimensional Recovery Trajectories Throughout Breast Cancer Treatment and Survivorship: A Prospective Longitudinal Study.Current oncology (Toronto, Ont.) · 2026Article
- Insomnia in Breast Cancer: A Neglected Symptom Cluster.Journal of clinical medicine · 2026Review
- Living beyond survival: Experiences of self-management among long-term breast cancer survivors - A qualitative study.International journal of nursing studies advances · 2026Article
- Quality of Life in Slovak Breast Cancer Survivors: A Cross-Sectional Study Using EORTC QLQ-C30 and BR23.Nursing reports (Pavia, Italy) · 2026Article
- Symptoms Experienced by Breast Cancer Patients Before, During and After Chemotherapy: A Systematic Review.International journal of women's health · 2026Review
- Peptide-Based Nanocarriers for Targeted Drug Delivery: Recent Advances, Strategies, and Therapeutic Frontiers.International journal of nanomedicine · 2026Review
- Symptom networks in breast cancer patients during chemotherapy and their impact on daily living status.Frontiers in oncology · 2026Article
- Transcutaneous vagus nerve stimulation in breast cancer: a neuroimmune model to improve quality of life.Frontiers in oncology · 2026Article
- Metabolomics-based exploration of the pathogenesis of breast cancer-related fatigue and progress of traditional Chinese medicine intervention.Frontiers in oncology · 2026Review
- Walking handball as an exercise alternative to conventional walking and recreational team handball.Frontiers in sports and active living · 2026Article
- Development and validation of a machine learning model to predict moderate-to-severe cancer-related fatigue in breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Genetic predisposition to persistent fatigue after a diagnosis of colorectal cancer.Journal of the National Cancer Institute · 2025Article
- Relationship between fatigue and self-compassion and associated factors in patients with hematological cancer: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Association of Genetic Predisposition to Inflammation With Cancer-Related Cognitive Impairment and Fatigue in Women Who Received Chemotherapy for Nonmetastatic Breast Cancer.JCO precision oncology · 2025Article
- Article
- Experiences of pain among Palestinian advanced cancer patients: a socio-cultural reading of reports from the Israeli occupied West Bank.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer-related fatigue (CRF) is one of the most common and distressing complaints reported by cancer patients during chemotherapy considerably impacting all aspects of a patient's life (physical, psychosocial, professional, and socioeconomic). The aim of this study was to assess the severity of cancer-related fatigue in a group of breast cancer patients undergoing chemotherapy and explore the association between fatigue scores and sociodemographic, clinical, biological, psychiatric, and genetic factors.
methodsA cross-sectional pilot study carried out at the oncology outpatient unit of Hôtel-Dieu de France University Hospital recruited 67 breast cancer patients undergoing chemotherapy between November 2017 and June 2019 to evaluate fatigue using the EORTC QLQ-C30 scale (European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire). Genotyping for seven gene polymorphisms (COMT, DRD2, OPRM1, CLOCK, PER2, CRY2, ABCB1) was performed using the Lightcycler
resultsThe prevalence of fatigue was 46.3%. Multivariable analysis taking the fatigue score as the dependent variable showed that a higher number of cycles and a lower hemoglobin level were significantly associated with higher odds of exhibiting fatigue. Moreover, having at least one C allele for DRD2 SNP (vs. TT) was significantly associated with a 4.09 higher odds of expressing fatigue compared to TT patients. Finally, patients with at least one C allele for CLOCK SNP tended to display higher fatigue levels than TT patients.
conclusionsOur study showed that anemic breast cancer patients with a high number of chemotherapy cycles and those carrying at least one C allele for DRD2 and CLOCK SNPs are at greater risk of exhibiting fatigue. Since no previous research has reported such genetic results, future studies are necessary to confirm our findings.
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