ArticleThe Journal of clinical investigation1987
Stimulation of human hematopoietic colony formation by recombinant gibbon multi-colony-stimulating factor or interleukin 3.
Article in The Journal of clinical investigation, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 134 citations in OpenAlex.
- Oncolytic and immunostimulatory efficacy of a targeted oncolytic poxvirus expressing human GM-CSF following intravenous administration in a rabbit tumor model.Cancer gene therapy · 2010Article
- The enhanced in vitro hematopoietic activity of leridistim, a chimeric dual G-CSF and IL-3 receptor agonist.Leukemia · 2002Article
- Erythropoietin-induced cellular differentiation requires prolongation of the G1 phase of the cell cycle.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Polycythemia vera blood burst-forming units-erythroid are hypersensitive to interleukin-3.The Journal of clinical investigation · 1991Article
- Review
- The Jeremiah Metzger lecture. Regulation of hematopoiesis.Transactions of the American Clinical and Climatological Association · 1990Review
- Reciprocal inhibition of binding between interleukin 3 and granulocyte-macrophage colony-stimulating factor to human eosinophils.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Stimulation of human prostatic carcinoma cell growth by factors present in human bone marrow.The Journal of clinical investigation · 1989Article
- Polypeptides controlling hematopoietic blood cell development and activation. II. Clinical results.Blut · 1989Review
- Mature T-lineage leukemia with growth factor-induced multilineage differentiation.The Journal of experimental medicine · 1989Article
- Polypeptides controlling hematopoietic cell development and activation. I. In vitro results.Blut · 1989Review
- Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Interleukin 1 stimulates T lymphocytes to produce granulocyte-monocyte colony-stimulating factor.The Journal of clinical investigation · 1988Article
- Numerous growth factors can influence in vitro megakaryocytopoiesis.The Yale journal of biology and medicineReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, the gene for a novel mammalian hematopoietic growth factor homologous to murine interleukin 3 was isolated from a gibbon T cell line and expressed in monkey COS cells. The factor, termed multi-colony stimulating factor (multi-CSF) or interleukin 3, is stimulatory to human target cells. We investigated the range of enriched human bone marrow and fetal liver hematopoietic progenitors responsive to multi-CSF; compared the colony types observed with those obtained in the presence of recombinant granulocyte-macrophage CSF (GM-CSF); and analyzed the effects on colony formation of combining multi-CSF with GM-CSF or granulocyte-CSF (G-CSF). The results show that multi-CSF acts as a multipoietin. Alone it stimulates the formation of colonies derived from granulocyte, macrophage, eosinophil, and megakaryocyte progenitors. In combination with erythropoietin it supports the development of both erythroid and mixed colonies. Furthermore, the data show that multi-CSF is a more potent stimulus of erythroid progenitors than GM-CSF. In combination with G-CSF multi-CSF substantially increases granulocyte colony number over the number obtained with each factor alone. We conclude that multi-CSF may prove to have important therapeutic potential in vivo as a stimulus for hematopoiesis.
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