Evidence map›Paper›PMID 34979477›Full record

ArticleBrain and language2022

Neural correlates of syntactic comprehension: A longitudinal study.

Shannon M Sheppard, Erin L Meier, Kevin T Kim, Bonnie L Breining, Lynsey M Keator, Bohao Tang, Brian S Caffo, Argye E Hillis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and language, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Atypical characteristic changes of surface morphology and structural covariance network in developmental dyslexia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shannon M SheppardDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Communication Sciences & Disorders, Chapman University, Irvine, CA 92618, United States. Electronic address: ssheppard@chapman.edu.
Erin L MeierDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Kevin T KimDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Bonnie L BreiningDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Lynsey M KeatorDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Bohao TangDepartment of Biostatics, Johns Hopkins School of Public Health, Baltimore, MD 21287, United States.
Brian S CaffoDepartment of Biostatics, Johns Hopkins School of Public Health, Baltimore, MD 21287, United States.
Argye E HillisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States; Department of Cognitive Science, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, United States.

Funding

Neural Basis of Lexical Deficits in Hyperacute StrokeR01DC005375 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI Argye E. Hillis · 2002 to 2026
$11.8M
The Neural Basis of Impaired Affective Prosody in Alzheimer's Disease and Frontotemporal DegenerationR01DC015466 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI HILLIS, ARGYE E. · 2017 to 2021
$3.5M
NIDCD NIH HHS R01 DC005375NIDCD NIH HHS R01 DC015466
6 · The paper itself

Abstract

Broca's area is frequently implicated in sentence comprehension but its specific role is debated. Most lesion studies have investigated deficits at the chronic stage. We aimed (1) to use acute imaging to predict which left hemisphere stroke patients will recover sentence comprehension; and (2) to better understand the role of Broca's area in sentence comprehension by investigating acute deficits prior to functional reorganization. We assessed comprehension of canonical and noncanonical sentences in 15 patients with left hemisphere stroke at acute and chronic stages. LASSO regression was used to conduct lesion symptom mapping analyses. Patients with more severe word-level comprehension deficits and a greater proportion of damage to supramarginal gyrus and superior longitudinal fasciculus were likely to experience acute deficits prior to functional reorganization. Broca's area was only implicated in chronic deficits. We propose that when temporoparietal regions are damaged, intact Broca's area can support syntactic processing after functional reorganization occurs.

Indexed as

ComprehensionStrokeBrain MappingFrontal LobeHumansLongitudinal StudiesMagnetic Resonance ImagingBroca’s areaLanguage comprehensionLesion-symptom mappingSentence processingSyntax

Identifiers

PMID34979477
PMCPMC9232253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.