Evidence map›Paper›PMID 34979450›Full record

ArticleRedox biology2022

Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder.

Hongrui Guo, Yujuan Ouyang, Heng Yin, Hengmin Cui, Huidan Deng, Huan Liu, Zhijie Jian, Jing Fang, Zhicai Zuo, Xun Wang and 4 more

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed
30.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 251 citations in OpenAlex.

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  19. Deficiency ofZoological research · 2026
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Hongrui GuoCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Yujuan OuyangCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Heng YinCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Hengmin CuiCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Agricultural Information Engineering of Sichuan Province, Sichuan Agriculture University, Yaan, Sichuan, 625014, China. Electronic address: chm2020@sicau.edu.cn.
Huidan DengCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China. Electronic address: denghuidan@sicau.edu.cn.
Huan LiuCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Zhijie JianCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Jing FangCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Zhicai ZuoCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Xun WangCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Ling ZhaoCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Yanqiu ZhuCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Yi GengCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Ping OuyangCollege of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper (Cu) is a necessary micronutrient at lower concentration, while excessive Cu exposure or Cu homeostasis disorders can lead to toxicity. The mechanism of male reproductive toxicity induced by Cu is still unknown. This study aims to investigate whether autophagy plays an important role in copper-induced spermatogenesis disorder in vivo and vitro. The present study showed that copper sulfate (CuSO

Indexed as

AMP-Activated Protein KinasesCopperAnimalsApoptosisAutophagyMaleMiceOxidative StressReactive Oxygen SpeciesSpermatogenesisTOR Serine-Threonine KinasesAMP-Activated Protein KinasesCopperReactive Oxygen SpeciesTOR Serine-Threonine KinasesApoptosisAutophagyCuSO(4)Oxidative stressSpermatogenesis disorder

Identifiers

PMID34979450
PMCPMC8728583
OpenAlexW4200078394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.