Evidence map›Paper›PMID 34979154›Full record

ReviewMicrovascular research2022

What is the impact of microvascular complications of diabetes on severe COVID-19?

Ruman Basra, Martin Whyte, Janaka Karalliedde, Prashanth Vas

Open access · greenAbstract readReview
In one paragraph

Review in Microvascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ruman BasraSchool of Cardiovascular Medicine & Sciences, King's College London, London, UK.
Martin WhyteDepartment of Clinical and Experimental Medicine, University of Surrey, Guildford, UK; Department of Diabetes, King's College NHS Foundation Trust, London, UK; King's Health Partners' Institute of Diabetes, Endocrinology and Obesity, London, UK.
Janaka KarallieddeSchool of Cardiovascular Medicine & Sciences, King's College London, London, UK; King's Health Partners' Institute of Diabetes, Endocrinology and Obesity, London, UK.
Prashanth VasDepartment of Diabetes, King's College NHS Foundation Trust, London, UK; King's Health Partners' Institute of Diabetes, Endocrinology and Obesity, London, UK. Electronic address: prashanth.vas@nhs.net.
King's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence suggests severe coronavirus disease-19 (COVID-19) infection is characterised by pulmonary and systemic microvasculature dysfunction, specifically, acute endothelial injury, hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in itself, confers an increased risk of adverse COVID-19 outcomes. It has been suggested that pre-existing endothelial dysfunction and microvascular disease in diabetes will exacerbate the vascular insults associated with COVID-19 and thus lead to increased severity of COVID-19 infection. In this article, we evaluate the current evidence exploring the impact of microvascular complications, in the form of diabetic retinopathy and nephropathy, in individuals with COVID-19 and diabetes. Future insights gained from exploring the microvascular injury patterns and clinical outcomes may come to influence care delivery algorithms for either of these conditions.

Indexed as

MicrocirculationPandemicsSARS-CoV-2AlbuminuriaCapillary PermeabilityCOVID-19Delivery of Health CareDiabetic AngiopathiesDiabetic NephropathiesDiabetic NeuropathiesDiabetic RetinopathyEndothelium, VascularHumansObesityPulmonary CirculationPulmonary EdemaAlbuminuriaCOVID-19DiabetesDiabetic nephropathyEndothelial dysfunctionMicrovascular diseaseRetinopathy

Identifiers

PMID34979154
PMCPMC8719364
OpenAlexW4205416044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.