Evidence map›Paper›PMID 34979036›Full record

ArticleAmerican journal on intellectual and developmental disabilities2022

Daily Living Skills in Adolescent and Young Adult Males With Fragile X Syndrome.

Angela John Thurman, Stephanie Summers Swinehart, Jessica Klusek, Jane E Roberts, Lauren Bullard, Jocelyn Christina B Marzan, W Ted Brown, Leonard Abbeduto

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in American journal on intellectual and developmental disabilities, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06997198 (Identification, Assessment, and Treatment of Tardive Dyskinesia With Deutetrabenazine in Adults With Intellectual/Developmental Disabilities and Co-occurring Psychiatric and/or Behavioral Disorders), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06997198 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Identification, Assessment, and Treatment of Tardive Dyskinesia With Deutetrabenazine in Adults With Intellectual/Developmental Disabilities and Co-occurring Psychiatric and/or Behavioral Disorders

TypeinterventionalSponsorUniversity Hospitals Cleveland Medical CenterRan2026 to 2027Enrolled25ConditionsTardive Dyskinesia, Intellectual Disability, Developmental DisabilitiesArmsDeutetrabenazine Oral Capsule
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Language Skills Influence Transition Planning in Adolescents With Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Angela John ThurmanAngela John Thurman and Stephanie Summers Swinehart, University of California Davis Health.
Stephanie Summers SwinehartAngela John Thurman and Stephanie Summers Swinehart, University of California Davis Health.
Jessica KlusekJessica Klusek and Jane E. Roberts, University of South Carolina.
Jane E RobertsJessica Klusek and Jane E. Roberts, University of South Carolina.
Lauren BullardLauren Bullard, University of California Davis Health.
Jocelyn Christina B MarzanJocelyn Christina B. Marzan, University of the Philippines-Manila, Philippines.
W Ted Brown. Ted Brown, University of Sydney and NYS Institute for Basic Research.
Leonard AbbedutoLeonard Abbeduto, University of California Davis Health.
University of California, Davis · USUniversity of South Carolina · USUC Davis Health System · USUniversity of Sydney · AUUniversity of the Philippines Manila · PH

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
LINGUISTIC COMMUNICATION AND MENTAL RETARDATIONR01HD024356 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ABBEDUTO, LEONARD J. · 1987 to 2022
$9.0M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VAN DE WATER, JUDY A. · 2013 to 2019
$8.5M
NCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR001860NICHD NIH HHS P50 HD103526NICHD NIH HHS R01 HD024356NICHD NIH HHS U54 HD079125
6 · The paper itself

Abstract

By adulthood, most males with fragile X syndrome (FXS) require support to navigate day-to-day settings. The present study cross-sectionally: (1) characterized the profile of daily living skills in males with FXS and (2) examined associated participant characteristics (i.e., fragile X mental retardation protein [FMRP] expression, nonverbal cognition, language, autism symptomatology, and anxiety symptomatology) using the Waisman-Activities of Daily Living questionnaire. Males with FXS (n = 57, ages 15-23 years) needed more help/support in the areas of domestic and community daily livings skills, than in the area of personal daily living skills. Significant associations were observed between reduced daily living skills and lower nonverbal cognition, receptive language, expressive language, and increased autism symptomatology. Receptive language emerged as the strongest unique predictor of daily living skill performance.

Indexed as

Autistic DisorderFragile X SyndromeActivities of Daily LivingAdolescentAdultHumansLanguageLanguage TestsMaleYoung Adultautism spectrum disorderdaily living skillsFMRPfragile X syndromelanguage

Identifiers

PMID34979036
PMCPMC8740615
OpenAlexW4206295825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.