ArticlePharmaceutical biology2022
A comprehensive study on the relieving effect of
Article in Pharmaceutical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- From alpha diversity to zeitgebers: Bacterial gut microbiome associations with sleep and circadian disruption (Part I).Neuroscience and biobehavioral reviews · 2026Review
- From alpha diversity to zeitgebers: Functional implications and potential mechanisms linking the gut microbiome to sleep and circadian disruption (Part II).Neuroscience and biobehavioral reviews · 2026Review
- The gut microbiota-metabolite-target axis in insomnia: network pharmacology and gut microbiota profiling insights into pathogenesis and intervention with Cinnamomi Cortex-Gardeniae Fructus.Frontiers in microbiology · 2026Article
- Tuina ameliorates sleep disturbances in PCPA-treated rats through Piezo1-mediated calcium signaling.Frontiers in pharmacology · 2026Article
- Integrating serum pharmacochemistry with network pharmacology and pharmacological validation to elucidate the mechanism of KaiXinSan in treating insomnia.BMC complementary medicine and therapies · 2025Article
- Role of traditional Chinese medicine in supporting liver transplantation outcomes.World journal of transplantation · 2025Article
- Impact of a standardized quality care model on anxiety in patients retained in the emergency department: A retrospective study.Medicine · 2025Article
- Gut microbiota and insomnia: Mendelian randomization and network pharmacology to predict potential intervention with traditional Chinese medicine.Archives of medical science : AMS · 2025Article
- Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications ofFrontiers in pharmacology · 2025Review
- Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches.Frontiers in neuroscience · 2025Review
- Gut microbiota: a new target for the prevention and treatment of insomnia using Chinese herbal medicines and their active components.Frontiers in pharmacology · 2025Review
- Huanglian Wendan Decoction Improves Insomnia in Rats by Regulating BDNF/TrkB Signaling Pathway Through Gut Microbiota-Mediated SCFAs and Affecting Microglia Polarization.Molecular neurobiology · 2025Article
- Insomnia and intestinal microbiota: a narrative review.Sleep & breathing = Schlaf & Atmung · 2024Review
- Research progress on the effect of medicine and food homology resources for sleep improvement.Heliyon · 2024Review
- Beta-Myrcene as a Sedative-Hypnotic Component from Lavender Essential Oil in DL-4-Chlorophenylalanine-Induced-Insomnia Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Integrative analysis of metabolome and transcriptome provides new insights into functional components ofChinese herbal medicines · 2024Article
- Melatonin enhances resistance to Botryosphaeria dothidea in pear by promoting jasmonic acid and phlorizin biosynthesis.BMC plant biology · 2024Article
- Cannabidiol Exerts Sedative and Hypnotic Effects in Normal and Insomnia Model Mice Through Activation of 5-HTNeurochemical research · 2024Article
- Herbal medicines in Alzheimer's disease and the involvement of gut microbiota.Frontiers in pharmacology · 2024Review
- Study on the effects of Massa Medicata Fermentata with different formulations on the intestinal microbiota and enzyme activities in mice with spleen deficiency constipation.Frontiers in cellular and infection microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe bulb of
objectiveTo investigate the molecular mechanism of LB relieving insomnia. MATERIALS AND
methodsInsomnia model was induced by intraperitoneally injection
resultsThe adverse changes in the abundance and diversity of intestinal flora and faecal metabolic phenotype altered by PCPA in rats were reversed after LB treatment, accompanied by the up-regulated levels of 5-HT as 8.14 ng/mL, MT as 16.16 pg/mL, 5-HT1A R and GABA
conclusionThe mechanism of LB relieving insomnia involves regulating flora and metabolites to resemble the control group. As a medicinal and edible herb, LB could be considered for development as a health-care food to relieve increasing insomniacs in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.