Evidence map›Paper›PMID 34978760›Full record

ArticleActa physiologica (Oxford, England)2022

Enhanced phosphate absorption in intestinal epithelial cell-specific NHE3 knockout mice.

Jianxiang Xue, Linto Thomas, Sathish Kumar Murali, Moshe Levi, Robert A Fenton, Jessica A Dominguez Rieg, Timo Rieg

Open access · bronzeAbstract read
In one paragraph

Article in Acta physiologica (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Distinct roles of ferric carboxymaltose and ferric derisomaltose on phosphate homeostasis in iron deficiency anemia.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025
    Article
  4. Article
  5. Article
  6. Vitamin DScientific reports · 2024
    Article
  7. New functions and roles of the NaPflugers Archiv : European journal of physiology · 2024
    Review
  8. Effect of supplementation withFrontiers in microbiology · 2024
    Article
  9. Pharmacology of Mammalian NaHandbook of experimental pharmacology · 2024
    Article
  10. Article
  11. Review
  12. Physiopathology of Phosphate Disorders.Advances in kidney disease and health · 2023
    Review
  13. SGLT2 inhibition effect on salt-induced hypertension, RAAS, and NaAmerican journal of physiology. Renal physiology · 2022
    Article
  14. Article
  15. Intestine-Specific NHE3 Deletion in Adulthood Causes Microbial Dysbiosis.Frontiers in cellular and infection microbiology · 2022
    Article
  16. The NaFrontiers in physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jianxiang XueDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Linto ThomasDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Sathish Kumar MuraliDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Moshe LeviDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, District of Columbia, USA.
Robert A FentonDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Jessica A Dominguez RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Timo RiegDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.ORCID 0000-0001-6082-662X
University of South Florida · USAarhus University · DKGeorgetown University · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Coordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6M
Role of Renal and Intestinal AC6 and NHE3 for Phosphate HomeostasisR01DK110621 · NIDDK · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI RIEG, TIMO · 2016 to 2020
$1.7M
Pharmacological Npt2a inhibition as a treatment for hyperphosphatemia in chronic kidney diseaseI01BX004968 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI RIEG, TIMO · 2021 to 2024
–
BLRD VA I01 BX004968NIDDK NIH HHS 1R01DK110621NIDDK NIH HHS DK076169NIDDK NIH HHS DK115255NIDDK NIH HHS R01 DK110621NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255
6 · The paper itself

Abstract

aimsThe kidneys play a major role in maintaining P

methodsMice underwent dietary P

resultsOn the control diet, NHE3

conclusionIntestinal NHE3 has a significant contribution to P

Indexed as

Epithelial CellsPhosphatesAnimalsHomeostasisIntestinal AbsorptionIntestinal MucosaMiceMice, KnockoutSodium-Hydrogen Exchanger 3PhosphatesSlc9a3 protein, mouseSodium-Hydrogen Exchanger 3chronic kidney diseasehomeostasisinhibitorintestinephosphatesodium-hydrogen exchanger 3

Identifiers

PMID34978760
PMCPMC9286053
OpenAlexW4206107147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.