ArticleArtificial organs2022
Inflow cannula position as risk factor for stroke in patients with HeartMate 3 left ventricular assist devices.
Article in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- CT-based cannula position predicts neurological risk in patients with HeartMate 3 LVAD.JHLT open · 2026Article
- The impact of position changes of the inflow cannula in LVAD patients.Turk gogus kalp damar cerrahisi dergisi · 2026Article
- Non-invasive analysis of pump parameter responses to orthostatic transitions in patients with fully magnetically levitated left ventricular assist devices.European heart journal. Digital health · 2026Article
- Influence of Preoperative Anatomical Characteristics on the Direction of Inflow Cannula in HeartMate 3.Artificial organs · 2025Article
- Stroke in patients with left ventricular assist device (LVAD): who is at risk?-a retrospective observational study at a tertiary care center.Frontiers in cardiovascular medicine · 2025Article
- Acquired blood platelet disorder in patients with end-stage heart failure after implantation of a continuous centrifugal-flow left ventricular assist device: A prospective cohort study.Research and practice in thrombosis and haemostasis · 2023Article
- Inflow cannula position as risk factor for stroke in patients with HeartMate 3 left ventricular assist devices.Artificial organs · 2022Article
- A Sensorless Modular Multiobjective Control Algorithm for Left Ventricular Assist Devices: A Clinical Pilot Study.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundA relation between the left ventricular assist device inflow cannula (IC) malposition and pump thrombus has been reported. This study aimed to investigate if the pump position, derived from chest X-rays in HeartMate 3 (HM3) patients, correlates with neurological dysfunction (ND), ischemic stroke (IS), hemorrhagic stroke (HS) and survival.
methodsThis analysis was performed on routinely acquired X-rays of 42 patients implanted with a HM3 between 2014 and 2017. Device position was quantified in patients with and without ND from frontal and lateral X-rays characterizing the IC and pump in relation to spine, diaphragm or horizontal line. The primary end-point was freedom from stroke and survival one-year after HM3 implantation stratified by pump position.
resultsThe analysis of X-rays, 33.5 (41.0) days postoperative, revealed a significant smaller IC angle of HM3 patients with ND versus no ND (0.1° ± 14.0° vs. 12.9° ± 10.1°, p = 0.005). Additionally, the IC angle in the frontal view, IS: 4.1 (20.9)° versus no IS: 13.8 (7.5)°, p = 0.004 was significantly smaller for HM3 patients with IS. Using receiver operating characteristics derived cut-off, IC angle <10° provided 75% sensitivity and 100% specificity (C-statistic = 0.85) for predicting IS. Stratified by IC angle, freedom from IS at 12 months was 100% (>10°) and 60% (<10°) respectively (p = 0.002). No significant differences were found in any end-point between patients with and without HS. One-year survival was significantly higher in patients with IC angle >10° versus <10° (100% vs. 71.8%, p = 0.012).
conclusionsIC malposition derived from standard chest X-rays serves as a risk factor for ND, IS and worse survival in HM3 patients.
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