Evidence map›Paper›PMID 34978660›Full record

ArticleDocumenta ophthalmologica. Advances in ophthalmology2022

Delayed-onset hypoxic cortical blindness: coming back from the abyss.

Alexandre Majoulet, Isabelle Audo, Cécile Goujard, Mathilde De Menthon, Fabrice Chaix, Pierre Safar, Marc Labetoulle, Antoine Rousseau

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Documenta ophthalmologica. Advances in ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Alexandre MajouletDepartment of Ophthalmology Assistance Publique - Hôpitaux de Paris, Service d'ophtalmologie, Hôpital Bicêtre, 78, Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
Isabelle AudoINSERM, CNRS, Institut de la Vision, Sorbonne Université, 75012, Paris, France.
Cécile GoujardDepartment of Internal Medicine and Clinical Immunology, Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin Bicêtre, France.
Mathilde De MenthonDepartment of Internal Medicine and Clinical Immunology, Assistance Publique - Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin Bicêtre, France.
Fabrice ChaixDepartment of Internal Medicine, Centre Hospitalier de Polynésie Française, 98713, Papeete, Tahiti, France.
Pierre SafarDepartment of Vision Rehabilitation, Fondation Hospitalière Sainte-Marie, Paris, France.
Marc LabetoulleDepartment of Ophthalmology Assistance Publique - Hôpitaux de Paris, Service d'ophtalmologie, Hôpital Bicêtre, 78, Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France.
Antoine RousseauDepartment of Ophthalmology Assistance Publique - Hôpitaux de Paris, Service d'ophtalmologie, Hôpital Bicêtre, 78, Rue du Général Leclerc, 94275, Le Kremlin Bicêtre, France. antoine.rousseau@aphp.fr.ORCID 0000-0003-2355-2804
Université Paris-Saclay · FRAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Sainte-Anne · FRCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report a case of typical delayed-onset hypoxic cortical blindness that occurred few days after resuscitation from drowning in a young male.

methodsNeurological and ophthalmological examination were performed including optical coherence tomography (OCT), Goldmann perimetry, pattern electroretinogram (pERG), pattern and flash visual evoked potentials (pVEP and fVEP) and brain magnetic resonance imaging (MRI).

resultsAt presentation, at day 12 post-hypoxic incident, best corrected visual acuity (BCVA) was reduced to hand motion OU with an abolished optokinetic nystagmus, a normal fundus and no relative afferent pupillary defect. Macular and peripapillary OCT were normal. Goldmann perimetry revealed bilateral centrocecal scotoma. pERG was normal while pVEPs were undetectable and fVEPs were abnormal with delayed, decreased and disorganized responses, without interhemispheric asymmetry. Brain MRI disclosed a bilateral cortical-subcortical occipital hypersignal with laminar necrosis and thus confirmed the diagnosis of delayed-onset hypoxic cortical blindness. Visual rehabilitation, including visual stimulation in the scotomatous areas, was associated with a dramatic and rapid visual improvement with a BCVA of 20/32 OU, an ability to read after 2 weeks (day 30 post-hypoxic incident), and a reduction in the size of the scotoma.

conclusionDelayed-onset hypoxic cortical blindness is a rare presentation of cortical blindness that develops few days after a cerebral hypoxic stress. While initial presentation can be catastrophic, visual improvement may be spectacular and enhanced with visual rehabilitation.

Indexed as

Blindness, CorticalElectroretinographyBlindnessEvoked Potentials, VisualHumansMaleScotomaTomography, Optical CoherenceVision DisordersApneaCortical blindnessVisual evoked potentialVisual rehabilitation

Identifiers

PMID34978660
OpenAlexW4206697201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.