ArticleJournal of proteome research2022
Targeted Metabolomic Approach to Assess the Reproducibility of Plasma Metabolites over a Four Month Period in a Free-Living Population.
Article in Journal of proteome research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Association of handgrip strength with the plasma metabolomic profile: secondary analysis of a protein intervention study.Metabolomics : Official journal of the Metabolomic Society · 2026Trial
- Prognostic value of perioperative changes in serum primary metabolites in patients after major surgery under general anesthesia: an exploratory secondary analysis of the TAPIR trial.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Trial
- Metabolic Phenotyping Identifies Responders to Sustainable Healthy Diets: Analysis from the MyPlanetDiet Randomized Controlled Trial.Current developments in nutrition · 2026Article
- MetaboVariation 2.0: Multivariate analysis for identifying metabolite variation at the individual level.PloS one · 2026Article
- Reproducibility and Sources of Variation of Urinary Biomarkers of Food Intake of Fruits, Vegetables, and Chocolate in European Children and Adolescents.The Journal of nutrition · 2026Article
- A multiplexed LC-MS/MS assay for comprehensive screening of amino acid metabolism disorders.Talanta open · 2025Article
- Intra-individual variability of the human seminal plasma metabolome.Asian journal of andrology · 2025Article
- Faecal microbiota and serum metabolome association with equine metabolic syndrome in connemara ponies.BMC veterinary research · 2025Article
- Simplex-structured matrix factorisation: application of soft clustering to metabolomic data.Scientific reports · 2025Article
- Association between the third trimester maternal serum metabolome and child growth and development through the first year of life.Scientific reports · 2024Article
- Association of plant-based diet indexes with the metabolomic profile.Scientific reports · 2024Article
- Reliability of Time-Series Plasma Metabolome Data over 6 Years in a Large-Scale Cohort Study.Metabolites · 2024Article
- Variability of the Human Serum Metabolome over 3 Months in the EXPOsOMICS Personal Exposure Monitoring Study.Environmental science & technology · 2023Article
- Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes.Immunology and cell biology · 2023Article
- Human Metabolome Reference Database in a Biracial Cohort across the Adult Lifespan.Metabolites · 2023Article
- Spatial metabolomics reveals skeletal myofiber subtypes.Science advances · 2023Article
- MetaboVariation: Exploring Individual Variation in Metabolite Levels.Metabolites · 2023Article
- Distinct patterns of personalised dietary advice delivered by a metabotype framework similarly improve dietary quality and metabolic health parameters: secondary analysis of a randomised controlled trial.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics is increasingly applied to investigate diet-disease associations in nutrition research. However, studies of metabolite reproducibility are limited, which could hamper their use within epidemiologic studies. The objective of this study was to evaluate the metabolite reproducibility during 4 months in a free-living population. In the A-DIET Confirm study, fasting plasma and dietary data were collected once a month for 4 months. Metabolites were measured using liquid chromatography tandem mass spectrometry, and their reproducibility was estimated using the intraclass correlation coefficient (ICC). Regularized canonical correlation analysis (rCCA) was employed to examine the diet-metabolite associations. In total, 138 metabolites were measured, and median ICC values of 0.49 and 0.65 were found for amino acids and biogenic amines, respectively. Acylcarnitines, lysophosphatidylcholines, phosphatidylcholines, and sphingomyelins had median ICC values of 0.69, 0.66, 0.63, and 0.63, respectively. The median ICC for all metabolites was 0.62, and 54% of metabolites had ICC values ≥0.60. Additionally, the rCCA heat map revealed positive correlations between dairy/meat intake and specific lipids. In conclusion, more than half of the metabolites demonstrated good to excellent reproducibility. A single measurement per subject could appropriately reflect the metabolites' long-term concentration levels and may also be sufficient for assessing disease risk in epidemiologic studies. The study data are deposited in MetaboLights (MTBLS3428 (www.ebi.ac.uk/metabolights)).
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