ReviewNMR in biomedicine2023
Chemical exchange saturation transfer imaging of creatine, phosphocreatine, and protein arginine residue in tissues.
Review in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- High-Temporal-Resolution Monitoring of Creatine and Phosphocreatine Dynamics in Skeletal Muscle Using Ultrafast Z-Spectroscopy (UFZ) CEST MRI at 3T.Magnetic resonance in medicine · 2026Article
- Enhanced Quantitative Phosphocreatine MR Imaging of Skeletal Muscle Using a Global-Local Two-Branch Deep Learning Model.Magnetic resonance in medicine · 2026Article
- Chemical exchange saturation transfer NMR: An analytical tool and its applications.Magnetic resonance letters · 2026Review
- Amide proton transfer-weighted magnetic resonance imaging for predicting histopathology and biomarkers in rectal adenocarcinoma.Quantitative imaging in medicine and surgery · 2026Article
- Denoising Low-Power CEST Imaging Using a Deep Learning Approach With a Dual-Power Feature Preparation Strategy.Magnetic resonance in medicine · 2026Article
- A rapid and accurate guanidine CEST imaging in ischemic stroke using a machine learning approach.Physics in medicine and biology · 2026Article
- Chemical exchange saturation transfer MRI for neurodegenerative diseases: An update on clinical and preclinical studies.Neural regeneration research · 2026Article
- MixBranchNet: a task-adaptive network for glioma segmentation and genotype prediction by exploiting spatial-spectral correlations in CEST MRI.Frontiers in oncology · 2026Article
- Prediction of MGMT promoter methylation in glioblastoma and grade 4 astrocytoma using fluid-suppressed chemical exchange saturation transfer MRI and machine learning-based segmentation.Frontiers in oncology · 2026Article
- Creatine-weighted imaging in patients with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Insights Into CEST Contrast at 2 ppm in Enhancing and Nonenhancing Lesions From Glioma Patients Scanned at 7 T.NMR in biomedicine · 2025Article
- Quantitative molecular imaging using deep magnetic resonance fingerprinting.Nature protocols · 2025Review
- Machine learning-based multi-pool Voigt fitting of CEST, rNOE, and MTC in Z-spectra.Magnetic resonance in medicine · 2025Article
- CESTsimu: An open-source GUI for spectral and spatial CEST simulation.Magnetic resonance in medicine · 2025Article
- Amide mapping in the human brain using downfield MRSI at 3 T and 7 T.Magnetic resonance in medicine · 2025Article
- Simultaneous monitoring of glycogen, creatine, and phosphocreatine in type II glycogen storage disease using saturation transfer MRI.Magnetic resonance in medicine · 2025Article
- Mitochondrial oxidative phosphorylation capacity in skeletal muscle measured by ultrafast Z-spectroscopy (UFZ) MRI at 3T.Magnetic resonance in medicine · 2025Article
- Brain temperature mapping based on chemical exchange saturation transfer signal at 2 ppm.Quantitative imaging in medicine and surgery · 2025Article
- Enhancing amide proton transfer imaging in ischemic stroke using a machine learning approach with partially synthetic data.NMR in biomedicine · 2025Article
- Elucidating metabolite and pH variations in stroke through guanidino, amine and amide CEST MRI: A comparative multi-field study at 9.4T and 3T.NeuroImage · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Chemical exchange saturation transfer (CEST) MRI has become a promising technique to assay target proteins and metabolites through their exchangeable protons, noninvasively. The ubiquity of creatine (Cr) and phosphocreatine (PCr) due to their pivotal roles in energy homeostasis through the creatine phosphate pathway has made them prime targets for CEST in the diagnosis and monitoring of disease pathologies, particularly in tissues heavily dependent on the maintenance of rich energy reserves. Guanidinium CEST from protein arginine residues (i.e. arginine CEST) can also provide information about the protein profile in tissue. However, numerous obfuscating factors stand as obstacles to the specificity of arginine, Cr, and PCr imaging through CEST, such as semisolid magnetization transfer, fast chemical exchanges such as primary amines, and the effects of nuclear Overhauser enhancement from aromatic and amide protons. In this review, the specific exchange properties of protein arginine residues, Cr, and PCr, along with their validation, are discussed, including the considerations necessary to target and tune their signal effects through CEST imaging. Additionally, strategies that have been employed to enhance the specificity of these exchanges in CEST imaging are described, along with how they have opened up possible applications of protein arginine residues, Cr and PCr CEST imaging in the study and diagnosis of pathology. A clear understanding of the capabilities and caveats of using CEST to image these vital metabolites and mitigation strategies is crucial to expanding the possibilities of this promising technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.