Evidence map›Paper›PMID 34978237›Full record

ArticleDrug delivery2022

Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice.

Hao Zhang, Mengyao Zhang, Xumei Wang, Mi Zhang, Xuelian Wang, Yiyang Li, Zhuoer Cui, Xiuping Chen, Yantao Han, Wenwen Zhao

Abstract read
In one paragraph

Article in Drug delivery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Advancements in Functional Polymeric Scaffolds for Scar-Free Skin Regeneration.Polymer science & technology (Washington, D.C.) · 2026
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  9. Lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells is inhibited by microRNA-494-3p via targeting lipoprotein-associated phospholipase A2.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  10. Review
  11. Soluble polyvinylpyrrolidone-based microneedles loaded with Sanguis draconis and Salvia miltiorrhiza for treatment of diabetic wound healing.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hao ZhangQingdao University Medical College, Qingdao, China.
Mengyao ZhangQingdao University Medical College, Qingdao, China.
Xumei WangState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Mi ZhangQingdao University Medical College, Qingdao, China.
Xuelian WangQingdao University Medical College, Qingdao, China.
Yiyang LiQingdao University Medical College, Qingdao, China.
Zhuoer CuiQingdao University Medical College, Qingdao, China.
Xiuping ChenState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
Yantao HanQingdao University Medical College, Qingdao, China.
Wenwen ZhaoQingdao University Medical College, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the worldwide prevalence of diabetes and considering the complicated microenvironment of diabetic wounds, the design and development of innovative multifunctional wound dressing materials are much wanted for the treatment of hard-to-heal wounds in diabetic patients. In the present study, anti-inflammatory ingredients loaded with nanofibrous wound dressing materials were manufactured by a promising blend-electrospinning strategy, and their capability for treating the diabetic wound was also systematically explored. A polymer blend consisting of Chitosan (CS) and polyvinyl alcohol (PVA) was electrospun into CS-PVA nanofibrous mats as control groups. In the meanwhile, a bioactive ingredient of Chinese medicine

Indexed as

AnimalsBiomimeticsCell SurvivalChitosanDiabetes Mellitus, ExperimentalDose-Response Relationship, DrugDrug LiberationInflammation MediatorsMacrophagesMiceNanofibersPolyvinyl AlcoholRAW 264.7 CellsSaponinsWound HealingWounds and Injuriesanemoside B4ChitosanInflammation MediatorsPolyvinyl AlcoholSaponinsanemoside B4diabetic wound healinginflammatoryTraditional Chinese medicine

Identifiers

PMID34978237
PMCPMC8725929

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.