Evidence map›Paper›PMID 34978168›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Ultrasensitive DNA-Biomacromolecule Sensor for the Detection Application of Clinical Cancer Samples.

Fengqin Li, Weiqiang Yang, Bingru Zhao, Shuai Yang, Qianyun Tang, Xiaojing Chen, Huili Dai, Peifeng Liu

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Breast Tumor Diagnosis Based on Molecular Learning Vector Quantization Neural Networks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fengqin LiState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China.
Weiqiang YangEmergency Department, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Bingru ZhaoState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China.
Shuai YangState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China.
Qianyun TangState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China.
Xiaojing ChenState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China.
Huili DaiState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China.
Peifeng LiuState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China.ORCID 0000-0001-7733-2511

Funding

Medical-Engineering Joint Funds from the Shanghai Jiao Tong University YG2021QN23Medical Trans-formation Crossing Funding from Shanghai Jiao Tong University ZH2018ZDA05National Natural Science Foundation of China 81771968Shanghai Municipal Commission of Health and Family Planning 201840020Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support 20181705Shanghai Sailing Program 21YF1444900
6 · The paper itself

Abstract

Diagnostic testing of biological macromolecules is of great significance for early warning of disease and cancer. Nevertheless, restricted by limited surface area and large steric hindrance, sensitive detection of macromolecules with interface-based sensing method remains challenging. Here, a "biphasic replacement" electrochemical aptamer-based (BRE-AB) sensing strategy which placed capture reaction of the biomacromolecule in a homogeneous solution phase and replaced with a small diameter of single-stranded DNA to attach to the interface is introduced. Using the BRE-AB sensor, the ultrasensitive detection of luteinizing hormone (LH) with the detection limit of 10 × 10

Indexed as

Aptamers, NucleotideBiosensing TechniquesDNA, Single-StrandedElectrochemical TechniquesHumansLimit of DetectionLuteinizing HormoneAptamers, NucleotideDNA, Single-StrandedLuteinizing Hormoneaptamersbiomacromolecules detectionclinical cancer sampleselectrochemicalluteinizing hormones

Identifiers

PMID34978168
PMCPMC8867190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.