ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Bioinspired Dormant-ATP-Stabilized Biomineral Amorphous Nanoparticles and Saliva-Activated Rapid Mineralization Toward High-Performance Dental Enamel Restoration.Advanced healthcare materials · 2026Article
- Biomimetic supramolecular protein matrix restores structure and properties of human dental enamel.Nature communications · 2025Article
- Recent Advances in Biomimetic Porous Materials for Real-World Applications.Biomimetics (Basel, Switzerland) · 2025Review
- Physical and chemical niche of human growth plate for polarized bone development.Nature communications · 2025Article
- Amphiphilic Janus nanoparticles for a superhydrophobic coating on the enamel surface to prevent caries.Materials today. Bio · 2025Article
- Evolution of Dental Resin Adhesives-A Comprehensive Review.Journal of functional biomaterials · 2025Review
- The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation.Nature communications · 2025Article
- Alendronate as Bioactive Coating on Titanium Surfaces: An Investigation of CaP-Alendronate Interactions.Materials (Basel, Switzerland) · 2024Article
- Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications.Micromachines · 2023Review
- A Study of the Peculiarities of the Formation of a Hybrid Interface Based on Polydopamine between Dental Tissues and Dental Composites, Using IR and Raman Microspectroscopy, at the Submicron Level.International journal of molecular sciences · 2023Article
- Intrafibrillar mineralization of type I collagen by micelle-loaded amorphous calcium phosphate nanoparticles.RSC advances · 2023Article
- Development of a Hybrid Biomimetic Enamel-Biocomposite Interface and a Study of Its Molecular Features Using Synchrotron Submicron ATR-FTIR Microspectroscopy and Multivariate Analysis Techniques.International journal of molecular sciences · 2022Article
- Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Advanced materials for enamel remineralization.Frontiers in bioengineering and biotechnology · 2022Review
- Promoting effect of a calcium-responsive self-assembly β-sheet peptide on collagen intrafibrillar mineralization.Regenerative biomaterials · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
Biomimetic mineralization based on self-assembly has made great progress, providing bottom-up strategies for the construction of new organic-inorganic hybrid materials applied in the treatment of hard tissue defects. Herein, inspired by the cooperative effects of key components in biomineralization microenvironments, a new type of biocompatible peptide scaffold based on flexibly self-assembling low-complexity protein segments (LCPSs) containing phosphate or phosphonate groups is developed. These LCPSs can retard the transformation of amorphous calcium phosphate into hydroxyapatite (HAP), leading to merged mineralization structures. Moreover, the application of phosphonated LCPS over phosphorylated LCPS can prevent hydrolysis by phosphatases that are enriched in extracellular mineralization microenvironments. After being coated on the etched tooth enamel, these LCPSs facilitate the growth of HAP to generate new enamel layers comparable to the natural layers and mitigate the adhesion of Streptococcus mutans. In addition, they can effectively stimulate the differentiation pathways of osteoblasts. These results shed light on the potential biomedical applications of two LCPSs in hard tissue repair.
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