Evidence map›Paper›PMID 34978148›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low-to-middle-income country.

Claudia K Suemoto, Laiss Bertola, Lea T Grinberg, Renata E P Leite, Roberta D Rodriguez, Pedro H Santana, Carlos A Pasqualucci, Wilson Jacob-Filho, Ricardo Nitrini

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  6. Culturally and linguistically diverse patients in an Italian memory clinic: lessons learned from the ImmiDem project.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Observational
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  17. Does Frailty Predict Cognitive and Functional Deficits After Nine Years?International journal of geriatric psychiatry · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Claudia K SuemotoDivision of Geriatrics, University of São Paulo Medical School, Sao Paulo, Brazil.ORCID 0000-0002-5942-4778
Laiss BertolaDivision of Geriatrics, University of São Paulo Medical School, Sao Paulo, Brazil.
Lea T GrinbergDepartment of Pathology, University of São Paulo Medical School, Sao Paulo, Brazil.
Renata E P LeiteDepartment of Pathology, University of São Paulo Medical School, Sao Paulo, Brazil.
Roberta D RodriguezDepartment of Neurology, University of São Paulo Medical School, Sao Paulo, Brazil.
Pedro H SantanaDivision of Geriatrics, University of São Paulo Medical School, Sao Paulo, Brazil.
Carlos A PasqualucciDepartment of Pathology, University of São Paulo Medical School, Sao Paulo, Brazil.
Wilson Jacob-FilhoDivision of Geriatrics, University of São Paulo Medical School, Sao Paulo, Brazil.
Ricardo NitriniDepartment of Neurology, University of São Paulo Medical School, Sao Paulo, Brazil.
Universidade de São Paulo · BR

Funding

Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progressionR01AG070826 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI GRINBERG, LEA TENENHOLZ, LIU, CHUNLEI · 2021 to 2025
$3.3M
Neuropathological changes underlying clinical heterogeneity in Alzheimer diseaseK24AG053435 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRINBERG, LEA TENENHOLZ · 2016 to 2025
$1.8M
NIA NIH HHS K24 AG053435NIA NIH HHS R01 AG060477NIA NIH HHS R01 AG070826
6 · The paper itself

Abstract

introductionEducation, and less frequently occupation, has been associated with lower dementia risk in studies from high-income countries. We aimed to investigate the association of cognitive impairment with education and occupation in a low-middle-income country sample.

methodsIn this cross-sectional study, cognitive function was assessed by the Clinical Dementia Rating sum of boxes (CDR-SOB). We investigated the association of occupation complexity and education with CDR-SOB using adjusted linear regression models for age, sex, and neuropathological lesions.

resultsIn 1023 participants, 77% had < 5 years of education, and 56% unskilled occupations. Compared to the group without education, those with formal education had lower CDR-SOB (1-4 years: DISCUSSION: Education, but not occupation, was related to better cognitive abilities independent of the presence of neuropathological insults.

Indexed as

Cognitive DysfunctionCognitive ReserveCognitionCross-Sectional StudiesEducational StatusHumansOccupationscognitive impairmentdeveloping countrieseducationoccupation

Identifiers

PMID34978148
PMCPMC9400335
OpenAlexW4206276886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.