ReviewThe journal of obstetrics and gynaecology research2022
Management of hemophagocytic lymphohistiocytosis in pregnancy: Case series study and literature review.
Review in The journal of obstetrics and gynaecology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- The Unfolding Mystery of Hemophagocytic Lymphohistiocytosis in Pregnancy: A Case Report.Cureus · 2026Article
- Hemophagocytic lymphohistiocytosis triggered by Hashimoto thyroiditis during pregnancy: a rare case report and diagnostic challenge.Annals of medicine and surgery (2012) · 2025Article
- Article
- Pregnancy-Associated Onset of Adult-Onset Still's Disease.AJP reports · 2024Review
- A Case Report of Pregnancy Complicated with Primary Hemophagocytic Lymphohistiocytosis.International journal of women's health · 2024Article
- Perioperative Management of Recurrent Hemophagocytic Syndrome in a Pregnant Woman: A Case Report.The American journal of case reports · 2023Article
- Haemophagocytic lymphohistiocytosis in pregnancy and the postpartum period: A retrospective case series analysis.NIHR open research · 2023Article
- Case report and literature review: Hemophagocytic lymphohistiocytosis in a pregnant woman with systemic lupus erythematosus withFrontiers in oncology · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aimThe diagnosis and treatment of hemophagocytic lymphohistiocytosis (HLH) in pregnancy is challenging due to its rarity. We aim to analyze and summarize the clinical characteristics of HLH in pregnancy, and to discuss effective diagnostic and treatment options.
methodsThirteen patients with HLH during pregnancy who were diagnosed and treated at the Peking Union Medical College Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2019 were studied retrospectively. We collected data on treatment regimens and on maternal and pregnancy outcomes.
resultsAll patients had a singleton pregnancy, with a median age of 28 years (range, 22-33 years) and a median gestational age of 23 weeks (7-36 weeks). Twelve patients received corticosteroids, and four patients (with/without intravenous immunoglobulin) showed a curative effect. Two patients who were treated with dexamethasone and etoposide after termination of pregnancy achieved complete remission. Two patients attained remission after termination of pregnancy. Four pregnant women died, and the mortality rate was 30.8% (4/13). Fetal or neonatal death up to 1 week after delivery occurred in eight (61.5%) pregnancies.
conclusionsEarly diagnosis and treatment are important for maternal survival, and corticosteroids are the first choice for most patients with HLH during pregnancy. For patients who do not respond to corticosteroids, etoposide and termination of pregnancy may be life-saving.
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