Evidence map›Paper›PMID 34978096›Full record

ArticleClinical oral implants research2022

Does new bone formation vary in different sites within the same maxillary sinus after lateral augmentation? A prospective histomorphometric study.

Claudio Stacchi, Antonio Rapani, Teresa Lombardi, Fabio Bernardello, Vanessa Nicolin, Federico Berton

Abstract read
In one paragraph

Article in Clinical oral implants research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Evaluation of I-PRF-Enriched Bone Graft Matrix (Sticky Bone) Among Patients Requiring Sinus Lift Operation: A Retrospective Comparative Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  3. Article
  4. [Imaging study of osteogenesis in maxillary sinus segment of zygomatic implants].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Claudio StacchiDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0003-4017-4980
Antonio RapaniDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0002-9767-4401
Teresa LombardiDepartment of Health Sciences, University 'Magna Graecia', Catanzaro, Italy.ORCID https://orcid.org/0000-0002-0334-6029
Fabio BernardelloPrivate Practice, Terranegra di Legnago (VR), Italy.ORCID https://orcid.org/0000-0001-6432-1549
Vanessa NicolinDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0002-5665-6493
Federico BertonDepartment of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.ORCID https://orcid.org/0000-0001-6359-9143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to evaluate histomorphometric outcomes of lateral maxillary sinus augmentation in different areas of the same cavity and to correlate results to bucco-palatal sinus width (SW) and residual bone height (RBH). MATERIAL AND

methodsPatients needing maxillary sinus floor elevation (RBH <5 mm) to insert two nonadjacent implants were treated with lateral augmentation using a composite graft. Six months later, two bone-core biopsies (mesial/distal) were retrieved in implant insertion sites. SW and RBH were measured on cone beam computed tomography, and correlations between histomorphometric and anatomical parameters were evaluated by multivariate linear regression analysis.

resultsTwenty patients underwent sinus augmentation, and eighteen were included in the final analysis (two dropouts for membrane perforation). Mean newly formed mineralized tissue percentage (%NFMT) after 6 months in mesial and distal sites was 17.5 ± 4.7 and 11.6 ± 4.7, respectively (p = .0004). Multivariate linear regression showed a strong negative correlation between SW and %NFMT (β coefficient=-.774, p < .0001) and no correlation between RBH and %NFMT (β coefficient =-.038, p = .825).

conclusionsThe present study confirms that %NFMT after lateral sinus augmentation occurs at different rates in different anatomical areas of the same maxillary sinus, showing a strong negative correlation with SW, whereas no influence of RBH was observed. Clinicians should regard SW as a guide for graft selection and to decide duration of the healing period. Researchers should consider SW as a predictor variable, when comparing regenerative outcomes of different biomaterials by using maxillary sinus as an experimental model.

Indexed as

Maxillary SinusSinus Floor AugmentationHumansMaxillaOsteogenesisProspective Studiesbone regenerationbone substitutesguided tissue regenerationmaxillary sinussinus floor elevation

Identifiers

PMID34978096
PMCPMC9306466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.