SynthesisWorld journal of pediatrics : WJP2022
Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis: a systematic review.
Synthesis in World journal of pediatrics : WJP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- The value of interleukin-6 in predicting acute appendicitis in children and distinguishing complicated appendicitis: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Diagnostic performance of calprotectin and APPY-1 test in pediatric acute appendicitis: a systematic review and a meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023Pooled it
- Comparison of Two Antibiotic Combinations for Conservative Treatment of Non-Complicated Appendicitis in Children.Medicina (Kaunas, Lithuania) · 2026Trial
- The diagnostic value of interleukin-6, procalcitonin, and C-reactive protein in the severity of acute appendicitis in children.Pediatric surgery international · 2026Article
- Diagnostic Performance of Interleukin-6 (IL-6) and Membrane Glycoprotein Cluster of Differentiation-64 (CD64) for Acute Appendicitis in Girls Presenting with Lower Abdominal Pain.Diagnostics (Basel, Switzerland) · 2026Article
- Serum immunoglobulin A in pediatric appendicitis.Scientific reports · 2026Article
- Clinical effect of fast-track surgery on laparoscopic treatment of pediatric acute appendicitis and its effect on abdominal inflammation and stress level.Pakistan journal of medical sciences · 2025Article
- Changes in Levels of Serum Cytokines and Chemokines in Perforated Appendicitis in Children.International journal of molecular sciences · 2024Article
- Associations between Th1-related cytokines and complicated pediatric appendicitis.Scientific reports · 2024Article
- Post-Traumatic Stress Response and Appendicitis in Children-Clinical Usefulness of Selected Biomarkers.Biomedicines · 2023Article
- Eosinophil Granule Proteins Involvement in Acute Appendicitis-An Allergic Disease?International journal of molecular sciences · 2023Article
- Trends and Predictors of Pediatric Negative Appendectomy Rates: A Single-Centre Retrospective Study.Children (Basel, Switzerland) · 2023Article
- Clinical Outcomes of Daytime Versus Nighttime Laparoscopic Appendectomy in Children.Children (Basel, Switzerland) · 2023Article
- The BIDIAP index: a clinical, analytical and ultrasonographic score for the diagnosis of acute appendicitis in children.Pediatric surgery international · 2023Article
- A Multiple-Array SPRi Biosensor as a Tool for Detection of Gynecological-Oncological Diseases.Biosensors · 2023Article
- Alterations and diagnostic performance of capillary ketonemia in pediatric acute appendicitis: a pilot study.Pediatric surgery international · 2022Article
- Diagnostic performance of serum pentraxin-3 in pediatric acute appendicitis: a prospective diagnostic validation study.Pediatric surgery international · 2022Article
- Discriminatory capacity of serum interleukin-6 between complicated and uncomplicated acute appendicitis in children: a prospective validation study.World journal of pediatrics : WJP · 2022Observational
- Serum neutrophil gelatinase-associated lipocalin (NGAL) as a diagnostic tool in pediatric acute appendicitis: a prospective validation study.Pediatric surgery international · 2022Observational
- Two Biosensors for the Determination of Interleukin-6 in Blood Plasma by Array SPRi.Biosensors · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the radiological and analytical advances of the last decades, there is still a significant rate of diagnostic error in pediatric acute appendicitis. In recent years, multiple biomarkers have emerged as potential diagnostic tools. This study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute appendicitis.
methodsWe conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography (Medline, PubMed, Web of Science and SciELO). Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion criteria. Methodological quality of the selected article was rated using the QUADAS2 index. Data extraction was performed by two independent reviewers.
resultsThe research in the medical bibliography databases resulted in 68 articles. We removed 26 duplicates. Among the remaining 42 articles, we excluded 33 following the inclusion and exclusion criteria. Of the final 9 studies included in this review, 8 provided measured serum interleukin-6 values, and all of them reported significant differences between groups, but inconsistent results regarding sensitivity and specificity.
conclusionsThe diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is limited. The sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated appendicitis. There seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute appendicitis. The increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated appendicitis. We consider that this may be an avenue of research to explore in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.