Evidence map›Paper›PMID 34977903›Full record

ArticleJACS Au2021

Substrate Dynamics Contribute to Enzymatic Specificity in Human and Bacterial Methionine Adenosyltransferases.

Madhuri Gade, Li Lynn Tan, Adam M Damry, Mahakaran Sandhu, Joseph S Brock, Andie Delaney, Alejandro Villar-Briones, Colin J Jackson, Paola Laurino

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. OrganophosphorusFrontiers in chemistry · 2024
    Article
  4. Article
  5. Article
  6. Mechanisms of protein evolution.Protein science : a publication of the Protein Society · 2022
    Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Madhuri GadeProtein Engineering and Evolution Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna 904-0495, Okinawa, Japan.
Li Lynn TanResearch School of Chemistry, Australian National University, Canberra, 2601, Australia.
Adam M DamryResearch School of Chemistry, Australian National University, Canberra, 2601, Australia.
Mahakaran SandhuResearch School of Chemistry, Australian National University, Canberra, 2601, Australia.
Joseph S BrockResearch School of Biology, Australian National University, Canberra 2601, Australia.
Andie DelaneyResearch School of Chemistry, Australian National University, Canberra, 2601, Australia.ORCID https://orcid.org/0000-0002-2068-3182
Alejandro Villar-BrionesProtein Engineering and Evolution Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna 904-0495, Okinawa, Japan.
Colin J JacksonResearch School of Chemistry, Australian National University, Canberra, 2601, Australia.ORCID https://orcid.org/0000-0001-6150-3822
Paola LaurinoProtein Engineering and Evolution Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna 904-0495, Okinawa, Japan.ORCID https://orcid.org/0000-0002-3725-2645
Australian National University · AUOkinawa Institute of Science and Technology Graduate University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein conformational changes can facilitate the binding of noncognate substrates and underlying promiscuous activities. However, the contribution of substrate conformational dynamics to this process is comparatively poorly understood. Here, we analyze human (hMAT2A) and

Identifiers

PMID34977903
PMCPMC8715544
OpenAlexW3216103694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.