Evidence map›Paper›PMID 34977888›Full record

ArticleJACS Au2021

Insights into the Interaction between Immobilized Biocatalysts and Metal-Organic Frameworks: A Case Study of PCN-333.

Wenjie Yang, Weibin Liang, Luke A O'Dell, Hamish D Toop, Natasha Maddigan, Xingmo Zhang, Alena Kochubei, Christian J Doonan, Yijiao Jiang, Jun Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Chemical science · 2023
    Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Wenjie YangLaboratory for Catalysis Engineering, School of Chemical and Biomolecular Engineering, Sydney Nano Institute, the University of Sydney, Sydney, NSW 2006, Australia.
Weibin LiangLaboratory for Catalysis Engineering, School of Chemical and Biomolecular Engineering, Sydney Nano Institute, the University of Sydney, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0002-3032-436X
Luke A O'DellInstitute for Frontier Materials, Deakin University, Geelong, VIC 3220, Australia.ORCID https://orcid.org/0000-0002-7760-5417
Hamish D ToopDepartment of Chemistry and the Centre for Advanced Nanomaterials, The University of Adelaide, Adelaide, South Australia 5005, Australia.ORCID https://orcid.org/0000-0003-4637-4764
Natasha MaddiganDepartment of Chemistry and the Centre for Advanced Nanomaterials, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Xingmo ZhangLaboratory for Catalysis Engineering, School of Chemical and Biomolecular Engineering, Sydney Nano Institute, the University of Sydney, Sydney, NSW 2006, Australia.
Alena KochubeiSchool of Engineering, Macquarie University, Sydney, NSW 2109, Australia.
Christian J DoonanDepartment of Chemistry and the Centre for Advanced Nanomaterials, The University of Adelaide, Adelaide, South Australia 5005, Australia.ORCID https://orcid.org/0000-0003-2822-0956
Yijiao JiangSchool of Engineering, Macquarie University, Sydney, NSW 2109, Australia.ORCID https://orcid.org/0000-0002-6191-9825
Jun HuangLaboratory for Catalysis Engineering, School of Chemical and Biomolecular Engineering, Sydney Nano Institute, the University of Sydney, Sydney, NSW 2006, Australia.ORCID https://orcid.org/0000-0001-8704-605X
The University of Sydney · AUThe University of Adelaide · AUMacquarie University · AUDeakin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immobilization of enzymes in metal-organic frameworks (MOFs) with preserved biofunctionality paves a promising way to solve problems regarding the stability and reusability of enzymes. However, the rational design of MOF-based biocomposites remains a considerable challenge as very little is known about the state of the enzyme, the MOF support, and their host-guest interactions upon immobilization. In this study, we elucidate the detailed host-guest interaction for MOF immobilized enzymes in the biointerface. Two enzymes with different sizes, lipase and insulin, have been immobilized in a mesoporous PCN-333(Al) MOF. The dynamic changes of local structures of the MOF host and enzyme guests have been experimentally revealed for the existence of the confinement effect to enzymes and van der Waals interaction in the biointerface between the aluminum oxo-cluster of the PCN-333 and the -NH

Identifiers

PMID34977888
PMCPMC8715483
OpenAlexW3214043531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.